Introduction Somatic mutations in isocitrate dehydrogenases (IDH1 or 2) are associated with elevated levels of 2-hydroxyglutarate (2HG), which may serve as a clinical biomarker for disease stratification and prognosis [1, 2]. However, the effects of IDH mutation or 2HG on cellular metabolism have not yet been elucidated [3]. Ex vivo and in vivo NMR spectroscopic methods using the stable C-label...

Heterozygous mutations in NADP-dependent isocitrate dehydrogenases (IDH) define the large majority of diffuse gliomas and are associated with hypermethylation of DNA and chromatin. The metabolic dysregulations imposed by these mutations, whether dependent or not on the oncometabolite D-2-hydroxyglutarate (D2HG), are less well understood. Here, we applied mass spectrometry imaging on intracrania...

The intermediate disturbance hypothesis (IDH) and the dynamic equilibrium model (DEM) are influential theories in ecology. The IDH predicts large species numbers at intermediate levels of disturbance and the DEM predicts that the effect of disturbance depends on the level of productivity. However, various indices of diversity are considered more commonly than the predicted number of species in ...

Previous determination of the nucleotide sequence of the iol region of the Bacillus subtilis genome allowed us to predict the structure of the iol operon for myo-inositol catabolism, consisting of 10 iol genes (iolA to iouJ); iolG corresponds to idh, encoding myo-inositol 2-dehydrogenase (Idh). Primer extension analysis suggested that an inositol-inducible promoter for the iol operon (iol promo...

Oligodendroglioma is characterized by mutations of IDH and CIC, 1p/19q loss, and slow growth. We found that NHE-1 on 1p is silenced in oligodendrogliomas secondary to IDH-associated hypermethylation and 1p allelic loss. Silencing lowers intracellular pH and attenuates acid load recovery in oligodendroglioma cells. Others have shown that rapid tumor growth cannot occur without NHE-1-mediated neu...

El artículo analiza el desarrollo de la interseccionalidad como concepto presente en proceso juzgar con perspectiva género, particular, su impacto jurisprudencia Corte Interamericana Derechos Humanos (Corte IDH). La metodología utilizada es cualitativa, principalmente, revisión sentencias IDH. De las 13 seleccionadas período 2015-2022 se concluye que IDH ha incorporado progresivamente intersecc...

Abstract Background Intradialytic hypotension (IDH) is one of the most frequent complications hemodialysis. IDH alters a patient’s quality life and has strong association with mortality. mainly occurs when ultrafiltration during hemodialysis exceeds pace plasma refill. Ultrasonography been used to evaluate intravascular volume status. We evaluated between baseline laboratory data or ultrasound ...

A method of mapping genes which specify enzymes without the necessity of obtaining genetic variants has been explored. Three enzymes whose structural genes have known genetic positions were chosen to see if the relationship between gene dosage and enzyme activity could be used as a tool in cytological localization. Zw, the gene specifying G6PD, is located in the X chromosome region, 18D-18F. Th...

We present two natalizumab-treated multiple sclerosis patients who developed glioblastoma multiforme (GBM) with variable outcomes. One patient had an isocitrate dehydrogenase (IDH)-wildtype GBM with aggressive behavior, who declined treatment and died 13 weeks after symptoms onset. The other patient underwent resection of an IDH-mutant secondary GBM that arose from a previously diagnosed grade ...