نتایج جستجو برای: icam

تعداد نتایج: 6532  

Journal: :American journal of physiology. Lung cellular and molecular physiology 2009
Suil Kim Jay A Nadel

Mucous hypersecretion is a serious feature of chronic airway diseases such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. Although mucins are produced via activation of an EGF receptor (EGFR) signaling cascade, the mechanisms leading to exaggerated mucin production in mucous hypersecretory diseases are unknown. Because expression of ICAM-1 and of the ICAM-1 ligand...

Journal: :Circulation research 2000
Y Zou Y Hu M Mayr H Dietrich G Wick Q Xu

Recently, we established a new mouse model of vein graft arteriosclerosis through the grafting of vena cava to carotid arteries. In many respects, the morphological features of this murine vascular graft model resemble those of human venous bypass graft disease. With this model, we studied the role of intercellular adhesion molecule-1 (ICAM-1) in the development of vein graft arteriosclerosis i...

Journal: :The American journal of physiology 1998
Carlton C Barnett Ernest E Moore Gary W Mierau David A Partrick Walter L Biffl David J Elzi Christopher C Silliman

Interaction of the β2-integrin complex on the polymorphonuclear neutrophil (PMN) with intercellular adhesion molecule-1 (ICAM-1) has been implicated in PMN-mediated cytotoxicity. This study examined interaction of the CD11a, CD11b, and CD18 subunits of the β2-integrin with ICAM-1, transfected into Chinese hamster ovarian (CHO) cells to avoid effects of other adhesion molecules. Incubation of qu...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2004
Alicia L Humlicek Liyi Pang Dwight C Look

Many cell types in the airway express the adhesive glycoprotein for leukocytes intercellular adhesion molecule-1 (ICAM-1) constitutively and/or in response to inflammatory stimuli. In this study, we identified functions of ICAM-1 on airway epithelial cells in defense against infection with Haemophilus influenzae. Initial experiments using a mouse model of airway infection in which the bacterial...

Journal: :Investigative ophthalmology & visual science 2010
Yoshio Hirano Eiji Sakurai Akihisa Matsubara Yuichiro Ogura

PURPOSE Leukocytes play a critical role in ocular diseases such as uveitis, diabetic retinopathy, and choroidal neovascularization. Intercellular adhesion molecule (ICAM)-1 is essential for the migration of leukocytes. Control of ICAM-1 expression may lead to therapies for these diseases. Small-interfering ribonucleic acids (siRNAs) are efficient specific modulators of endogenous gene expressio...

Journal: :Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1997
A R Farina L Cappabianca A R Mackay A Tiberio A Tacconelli A Tessitore L Frati S Martinotti A Gulino

In this study, the regulatory elements involved in ICAM-1 transcriptional response to phorbol ester (12-0-tetradecanoylphorbol-13-acetate; TPA) have been investigated in the human neuroblastoma cell line, SK-N-SH. TPA induced intercellular adhesion molecule 1 (ICAM-1) protein expression in SK-N-SH cells within 24 h of treatment as judged by indirect immunofluorescence. Basal ICAM-1 mRNA levels ...

Journal: :The Journal of Cell Biology 1994
M R Campanero P Sánchez-Mateos M A del Pozo F Sánchez-Madrid

Leukocyte activation is a complex process that involves multiple cross-regulated cell adhesion events. In this report, we investigated the role of intercellular adhesion molecule-3 (ICAM-3), the third identified ligand for the beta 2 integrin leukocyte function-associated antigen-1 (LFA-1), in the regulation of leukocyte adhesion to ICAM-1, vascular cell adhesion molecule-1 (VCAM-1), and the 38...

Journal: :The Journal of Cell Biology 1997
Juan M. Serrador José L. Alonso-Lebrero Miguel A. del Pozo Heinz Furthmayr Reinhard Schwartz-Albiez Javier Calvo Francisco Lozano Francisco Sánchez-Madrid

During activation, T lymphocytes become motile cells, switching from a spherical to a polarized shape. Chemokines and other chemotactic cytokines induce lymphocyte polarization with the formation of a uropod in the rear pole, where the adhesion receptors intercellular adhesion molecule-1 (ICAM-1), ICAM-3, and CD44 redistribute. We have investigated membrane-cytoskeleton interactions that play a...

Journal: :Journal of cell science 1992
K L Sung P Kuhlman F Maldonado B A Lollo S Chien A A Brian

Little is known in quantitative terms about forces between cells generated during adhesion and recognition, or about the contribution of any one set of molecular associations to the development of these forces. To determine the forces involved in adhesion dependent on lymphocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule 1 (ICAM-1), we have measured the junctional...

Journal: :Journal of immunology 2011
Nurit Hadad Liron Tuval Vered Elgazar-Carmom Ron Levy Rachel Levy

The regulated expression of ICAM-1 plays an important role in inflammatory processes and immune responses. The present study aimed to determine the in vivo involvement of cytosolic phospholipase A(2)α (cPLA(2)α) in ICAM-1 overexpression during inflammation and to elucidate the cPLA(2)α-specific role in signal events leading to ICAM-1 upregulation in endothelial cells. cPLA(2)α and ICAM-1 upregu...

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