Laminin (LM)-332 is an extracellular matrix protein that plays a structural role in normal tissues and is also important in facilitating recovery of epithelia from injury. We have shown that expression of LM-332 is up-regulated during renal epithelial regeneration after ischemic injury, but the molecular signals that control expression are unknown. Here, we demonstrate that in Madin-Darby canin...

We present a latent variable structured prediction model, called the Latent Left-linking Model (L3M), for discriminative supervised clustering of items that follow a streaming order. LM admits efficient inference and we present a learning framework for LM that smoothly interpolates between latent structural SVMs and hidden variable CRFs. We present a fast stochastic gradientbased learning techn...

IMPORTANCE Lentigo maligna (LM) is a clinical, pathologic, and therapeutic challenge with a higher risk of local recurrence than other types of melanoma correctly treated and also carries the cosmetically sensitive localization of head and neck. OBJECTIVE To determine whether in vivo reflectance confocal microscopy (RCM) mapping of difficult LM cases might alter patient care and management. ...

background: multi-specie biofi lms are highly resistant to antimicrobials due to cellular interactions found in them. the purpose of this study was to evaluate, by confocal laser scanning microscopy, the biofi lm dissolution effectiveness of different irrigant solutions on biofi lms developed on infected dentin in situ. materials and methods: a total of 120 bovine dentin specimens infected intr...

Esophageal axial shortening is caused by longitudinal muscle (LM) contraction, but circular muscle (CM) may also contribute to axial shortening because of its spiral morphology. The goal of our study was to show patterns of contraction of CM and LM layers during peristalsis and transient lower esophageal sphincter (LES) relaxation (TLESR). In rats, esophageal and LES morphology was assessed by ...

Human vision can detect spatiotemporal information conveyed by first-order modulations of luminance and by second-order, non-Fourier modulations of image contrast. Models for second-order motion have suggested two filtering stages separated by a rectifying nonlinearity. We explore here the encoding of stationary first-order and second-order gratings, and their interaction. Stimuli consisted of ...

BACKGROUND There is limited data on the impact of specific patient characteristics, tumor subtypes or treatment interventions on survival in breast cancer LM. METHODS A systematic review was conducted to assess the impact of hormone receptor and HER-2 status on survival in breast cancer LM. A search for clinical studies published between 1/1/2007 and 7/1/2012 and all randomized-controlled tri...

AIM Open myomectomy (OM) was previously frequently performed; however, laparoscopic myomectomy (LM) has recently become more common. Nevertheless, myoma can recur after both LM and OM. In this study, we report our retrospective investigation of myoma recurrence by comparing LM and OM. METHODS A total of 474 patients underwent LM and 279 patients underwent OM. The patients were followed-up pos...

Perceptual learning was used as a tool for studying motion perception. The pattern of transfer of learning of luminance- (LM) and contrast-modulated (CM) motion is diagnostic of how their respective processing pathways are integrated. Twenty observers practiced fine direction discrimination with either additive (LM) or multiplicative (CM) mixtures of a dynamic noise carrier and a radially isotr...

The type I interferon (IFN) activated transcriptional response is a critical antiviral defense mechanism, yet its role in bacterial pathogenesis remains less well characterized. Using an intracellular pathogen Listeria monocytogenes (Lm) as a model bacterial pathogen, we sought to identify the roles of individual interferon-stimulated genes (ISGs) in context of bacterial infection. Previously, ...