Endoglycoceramidase (EGCase) cleaves the linkage between oligosaccharides and ceramides of various glycosphingolipids (Ito, M., and Yamagata, T. (1986) J. Biol. Chem. 261, 14278-14282). Recently, by extensive purification, it was separated from cell-lytic factor (hemolysin) and found to consist of three molecular species each with its own specificity (EGCases I, 11, and 111) (Ito, M., and Yamag...

The purpose of the present field study was to examine the predictions of Multidimensional Anxiety Theory (MAT; Martens et a]., 1990) with elite male wheelchair basketball players. Thirty-seven elite male wheelchair basketball players completed the CSAI-I1 prior to each of three tournament games. Results were analyzed using the intraindividual procedures recommended by Sonstroem and Bernado (198...

Proliferating cell nuclear antigen (PCNA) plays an essential role in DNA replication and repair. Tumor cells express high levels of PCNA, identifying it as a potentially ideal target for cancer therapy. Previously, we identified nine compounds termed PCNA inhibitors (PCNA-Is) that bind directly to PCNA, stabilize PCNA trimer structure, reduce chromatin-associated PCNA, and selectively inhibit t...

This is the supplementary material for “Labeling Gaps Between Words: Recognizing Overlapping Mentions with Mention Separators” (Muis and Lu, 2017). This material explains in more depth the issue of spurious structures and also the experiments settings. 1 Details on Spurious Structures About mention hypergraph, we remarked in Section 3.1 that the normalization term calculated by the forward-back...

1. Angiotensin I1 together with any immunoreactive fragments of angiotensin were measured in arterial and venous plasma before and during infusion of angiotensin I1 amide in five normotensive subjects, both in sodium-replete and sodium-depleted states. Because the antibody used in the radioimmunoassay cross-reacted with larger angiotensin breakdown products and because these fragments are prese...

Numerous studies support the concept that centrally acting antihypertensive drugs, such as imidazolines, mediate sympathoinhibition not only via activation of central nervous alpha2-adrenoceptors (alpha2-AR) but also via imidazoline-1 receptors (I1-R). An additional presynaptic involvement in sympathetic neurotransmission of imidazolines, via I1-R independent of alpha2-AR, is still controversia...

Heterotrimeric Gi proteins play a role in lipopolysaccharide (LPS) and Staphylococcus aureus (SA) activated signaling leading to inflammatory mediator production. We hypothesized that genetic deletion of Gi proteins would alter cytokine and chemokine production induced by LPS and SA. LPS- and heat killed SA-induced cytokine and chemokine production in splenocytes from wild type (WT), Galpha(i2)...

Receptor activity modifying proteins (RAMPs) constitute a group of three proteins, designated as RAMP1, 2, and 3, which are able to effect functional changes in some members of the G protein-coupled receptor family. Thus, RAMP1 or RAMP3 can modify the calcitonin receptor (CTR) to also function as a high-affinity amylin receptor-like phenotype. To examine the RAMP/CTR interaction, individual RAM...