The proprotein convertases (PCs) are calcium-dependent proteases responsible for processing precursor proteins into their active forms in eukariotes. The PC1/3 is a pivotal enzyme of this family that participates in the proteolytic maturation of prohormones and neuropeptides inside the regulated secretory pathway. In this paper we demonstrate that mouse proprotein convertase 1/3 (mPC1/3) has a ...

This paper investigates an alternative mass sensing technique based on nonlinear micro/nanoelectromechanical resonant sensors. The proposed approach takes advantage of multi-stability and bifurcations of the hysteretic frequency responses of the electrostatically-actuated resonator. For this purpose, a reduced-order model is considered. Numerical results show that sudden jumps in amplitude make...

In this paper the semi-active control is achieved by a base isolation system. The magnetorheological dampers (MRD) hysteretic force is described by models based on nonlinear differential equation Bouc-Wen. The Bouc-Wen model is able to capture, in an analytical form, a range of shapes of hysteretic cycles which match the behavior of a wide class of nonlinear systems. In order to reduce the seis...

With the development of high-speed railway in recent years, lots of researchers have been paying more and more attention to the seismic isolation of high-speed railway bridge. The equivalent linear model of hysteretic characteristics of lead rubber bearings (LRB) is presented, the computational method and the varying range of dynamic parameters effecting hysteretic characteristics of LRB are es...

This paper describes the development of a new piezohydraulic actuator for broadband microjet flow control applications. The actuator utilizes a lead zirconate titanate (PZT) stack actuator and a hydraulic amplification design to achieve relatively large displacements in a compact actuator to control flow through a microjet orifice. Displacement amplification of 81 times the stack actuator displ...

The problem of state estimation in induction motors is considered in this paper. In most previous works, motor observers have been designed using standard models, neglecting the saturation and hysteretic effects in the machine magnetic circuit. As a matter of fact, these effects cannot be ignored especially when considering (speed, torque) control strategies involving wide range flux variations...

Subsurface two-phase flow in porous media often takes place in reservoirs with a high ratio between the associated lateral and vertical extent and the lateral and vertical flow time scales. This allows for a two-scale approach with effective quantities for two-dimensional horizontal flow equations obtained from reconstructed hydrostatic vertical pressure and saturation distributions. Here, we d...

To investigate the seismic behavior of end-plate connection semi-rigid space steel frames, three 1/4-scale specimens were tested under cyclic load. Finite element analysis which took initial geometric imperfections into consideration was also conducted, and the results conform to experimental results. The failure modes, hysteretic behavior, deformation capacity and energy-dissipation capacity o...