#### Notable in Neurology This Week issue features an article that evaluates long-term health care costs of surgery children with drug-resistant epilepsy; another defines and determines predictability poor cognitive outcome 1 year after mild traumatic brain injury. A featured Special Article provides a practice advisory update from the American Academy for stroke prevention patients symptomatic...

AIM To examine the dynamic changes of TNF-α, IL-6, IL-10, and GDNF (glial cell-derived neurotrophic factor) in serum or brain tissues of neonatal rat with hypoxic-ischemic encephalopathy and to explore their roles in neuronal apoptosis. MATERIALS AND METHODS A total of 80 Wistar rats were randomly divided into the sham-operated (control) group and the hypoxia-ischemia (HI) group. To establish...

Background: The present study aimed to investigate the prevalence of electrolyte imbalance in hypoxic-ischemic encephalopathy (HIE). Moreover, the correlation of this condition with Apgar score is evaluated. Methods: This prospective observational hospital-based study was conducted on 75 neonates affected by asphyxiation. Immediately (within ...

Neonatal hypoxic ischemic encephalopathy (HIE) is a common health problem and occurs in approximately 16 in 1000 term infants every year. After the initial hypoxic ischemic insult, brain injury evolves for days and possibly even weeks. The severity of the injury depends on the gestational age and duration of the insult. The exact underlying mechanisms of neonatal HIE remain undefined and many d...

Hypoxic-Ischemic Encephalopathy (HIE) is the consequence of systemic asphyxia occurring at birth. Twenty five percent of neonates with HIE develop severe and permanent neuropsychological sequelae, including mental retardation, cerebral palsy, and epilepsy. The outcomes of HIE are devastating and permanent, making it critical to identify and develop therapeutic strategies to reduce brain injury ...

Investigators from Children's National Medical Center and George Washington University School of Medicine, Washington, DC, studied the correlation between white matter tract changes and developmental outcomes in a series of infants with hypoxic ischemic encephalopathy (HIE) treated with whole body cooling.

OBJECTIVE To determine underlying risk factors in neonates with hypoxic ischemic encephalopathy. STUDY DESIGN Case-control study. PLACE AND DURATION OF STUDY Neonatology Unit at the Children's Hospital and the Institute of Childhealth, Lahore, from March to July 2005. PATIENTS AND METHODS All neonates (153) with the diagnosis of Hypoxic Ischemic Encephalopathy (HIE) were included in the s...

Isolated sulfite oxidase deficiency is a rare, autosomal recessive disease with a very poor prognosis. This condition usually presents in the neonatal period and is mainly characterized by neurological abnormalities, including refractory seizures, abnormal muscle tone, abnormal movements, and marked developmental delay. The differentiation from hypoxic-ischemic encephalopathy is difficult based...

OBJECTIVE To investigate the effects of hypothermia treatment on magnetic resonance imaging (MRI) patterns of brain injury in newborns with hypoxic-ischemic encephalopathy compared with normothermia, including the prognostic utility of MRI for death and/or disability at a postnatal age of 2 years. DESIGN Substudy of a randomized controlled trial. SETTING Participating centers in the Infant ...

Despite the important advances in perinatal care in the past decades, asphyxia remains a severe condition leading to significant mortality and morbidity. Perinatal asphyxia has an incidence of 1 to 6 per 1,000 live full-term births, and represents the third most common cause of neonatal death (23%) after preterm birth (28%) and severe infections (26%). Many preconceptional, antepartum and intra...