BACKGROUND Hypomagnesaemia is a common side effect of cyclosporin A (CsA) therapy. Animal studies suggest that magnesium (Mg) supplementation inhibits chronic CsA nephropathy. METHODS To determine if low Mg levels correlate with true CsA-induced nephrotoxicity in humans, we examined kidney transplant biopsy records at our centre for all transplant biopsies performed between 1990 and 2002. We ...

Chronic renal failure (CRF) alters the metabolism for a number of elements, and can lead to deficiency of these nutrients. Among the causes of thes alterations are reduced food intake and the low element content of some low-protein diets recommended in CRF. This study aimed to determine whether nutritional status for magnesium and zinc were changed by a nutritional intervention providing patien...

T h e development of hypomagnesaemia in calves to the stage at which tetanic convulsions occur has been shown experimentally by Blaxter, Rook & MacDonald (1954) to be a comparatively slow process. In contrast, hypomagnesaemic tetany can develop in the dairy cow and lactating ewe with great rapidity (Rook & Balch, 1958; L'Estrange & Axford, 1963). The increased speed of the development of the co...

BACKGROUND Cisplatin is an effective anti-neoplastic drug, but its clinical use is limited due to dose-dependent nephrotoxicity. The majority of cisplatin-treated patients develop hypomagnesaemia, often associated with a reduced glomerular filtration rate (GFR), polyuria and other electrolyte disturbances. The aim of this study is to unravel the molecular mechanism responsible for these particu...