BACKGROUND In subjects with hypercholesterolaemia, cholesterol values remain above guideline levels. One of the limiting factors to the achievement of goals in such patients is therapeutic non-adherence. The aim of this study is to assess the effectiveness of an intervention designed to improve control of hypercholesterolaemic patients, consisting of a combined strategy that would include the d...

BACKGROUND Obesity-associated type 2 diabetes is rapidly increasing throughout the world. It is generally recognized that natural products with a long history of safety can modulate obesity. AIM To investigate the development of obesity in response to a high fat diet (HFD) and to estimate the effect of L-carnitine and an Egyptian Herbal mixture formulation (HMF) (consisting of T. chebula, Sen...

Clofibrate and an alternative hypolipidaemic drug, tiadenol, cause hepatomegaly with marked proliferation of peroxisomes and mitochondria (Hess et al., 1965; Kurup et a/., 1970; Roze et al., 1977). Subcellular fractionation studies have shown that the palmitoyl-CoA hydrolase activity is present both in the microsomal and mitochondrial fractions (Berge & Farstad, 1979; Berge & Dassland, 1979). A...

During their classic studies on the Separation of lysosomes by centrifugation of rat liver homogenates, De Duve and bis group (1) observed that certain oxidative enzymes, such äs Z)-amino acid oxidase and uric acid oxidase wbich produce hydrogen peroxide, and catalase which attacks hydrogen peroxide, were always found in a discrete fraction which could be separated from lysosomes and mitochondr...

lesterol levels and cardiovascular disease is indisputable. High cholesterol is a major, modifiable risk factor for the development of coronary artery disease. Randomised studies have shown the benefit of the pharmacological modification of cholesterol in patients with established coronary artery disease (secondary prevention), as well as in healthy individuals with a high risk of coronary arte...

OBJECTIVE Adult onset GH deficiency (GHD) is characterized by abnormalities of serum lipoprotein profiles and GH replacement results in favourable alterations in serum total and low density lipoprotein (LDL)-cholesterol. Preliminary evidence has indicated that the effect of GH replacement in this respect may be additive to that of HMG CoA reductase inhibitor (statin) therapy. We have examined t...

The PPARs (peroxisome-proliferator-activated receptors) α, β/δ and γ belong to the nuclear hormone receptor superfamily. While all three receptors are undetectable in adult mouse interfollicular epidermis, PPARβ expression and activity is strongly re-activated by inflammatory stimuli during epidermal injury. The pro-inflammatory cytokine TNFα (tumour necrosis factor α) stimulates transcription ...

Dengue Fever (DF), a type of viral disease, is now almost an endemic to certain tropical and subtropical regions of the world. (Kadir et al., 2013; Senthilvel et al., 2013; Pigili et al., 2014; Abrao et al., 2015). According to Dengue Situation Update (Number 474) by World Health Organization, as on September 12, 2015, there were 85,488 dengue cases with 234 deaths reported in Malaysia for the ...

Dötsch et al. reported in this journal (1) on Blüher and co-worker’s evaluation of the 18% increase in the lifespan of fat-specific insulin receptor knockout (FIRKO) mouse (2). As early as 3 months of age, these mice maintained a body weight approximately 20% below the body weight of their control littermates. The reduction in body weight was caused by an approximately 60% reduction of fat tiss...

The association of an elevated level of lipoprotein (a) (Lp(a)) with the development of coronary heart disease (CHD) remains controversial. Lp(a) was investigated as a CHD risk factor in the PRIME Study, a prospective cohort study which included 9133 French and Northern Irish men aged 50-59 at entry, without a history of CHD and not on hypolipidaemic drugs. During a follow-up of 5 years, 288 su...