benzodiazepines (bzds) are widely used in clinical practice as anxiolytics, hypnotics, anticonvulsants, and muscle relaxants. however, they have some undesired effects including memory problems. in continuing our research on novel benzodiazepine ligands, we are looking for ligands with less adverse effects. previously, 4 novel derivatives of 2-phenoxy phenyl-1,3,4-oxadiazole were synthesized as...

separation of ten sedative- hypnotic drugs was performed by rp-hplc using mixed micellar mobile phase. effect of temperature, type and amount of organic modifier in mobile phase on efficiency (n) and asymmetry factor (b/a) showed that, the appropriate conditions for a good separation were 35°c and 7% (v/v) butanol in mobile phase.  variations of selectivity factor versus butanol concentration, ...

Benzodiazepines (BZDs) are widely used in clinical practice as anxiolytics, hypnotics, anticonvulsants, and muscle relaxants. However, they have some undesired effects including memory problems. In continuing our research on novel benzodiazepine ligands, we are looking for ligands with less adverse effects. Previously, 4 novel derivatives of 2-phenoxy phenyl-1,3,4-oxadiazole were synthesized as...

Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by the newly emerging SARS-CoV-2 virus that was first reported in December 2019 and was announced as a pandemic disease on March 11th, according to a World Health Organization (WHO) warning (1). SARS-CoV-2 is mainly transmitted through respiratory droplets and close contact, accordingly, requires treatment in isolation. I...

Abstract Introduction Clinicians prescribing hypnotics remain concerned regarding the inability to discontinue after chronic use. In a controlled prospective study using self-administration choice procedures we tested whether BZRA hypnotic receptor specificity is predictive of discontinuation difficulty in clinical trial which insomnia subjects are instructed stop taking their medication 6 mont...

The most well-established finding gleaned from decades of experimental hypnosis research is that individuals display marked variability in responsiveness to hypnotic suggestions. Insofar as this va...

In the present study, four non-drug-abusing humans were trained to discriminate between a hypnotic dose of pentobarbital, 100 mg, and placebo. After acquiring the pentobarbital-placebo discrimination, a range of doses of zolpidem, triazolam, pentobarbital and caffeine were tested to determine whether they shared discriminative stimulus effects with the training dose of pentobarbital, Zolpidem, ...