620 T he Multiple Sleep Latency Test (MSLT) is an important tool in the evaluation of excessive daytime sleepiness. It is indicated for the diagnosis of narcolepsy and the evaluation of idiopathic hypersomnia. 1 However, the MSLT results can be affected by a variety of extraneous variables that must be controlled or minimized to obtain interpretable diagnostic data. 2 Prior sleep deprivation is...

Abstract Introduction Obesity is one of the biggest public health problems in world, with incidence obesity estimated to be around 30% some countries. There a well-established link between Obstructive Sleep Apnea and obesity. This due many factors including narrower airway because fat deposits this region, as well decreased muscle activity. Subjective sleepiness measured Epworth Sleepiness Scal...

Abstract Introduction Narcolepsy type 1 is caused by destruction of hypocretin-producing neurons, likely via a T-cell mediated autoimmune process, and clinically identified either CSF hypocretin deficiency or the presence cataplexy. Individuals with narcolepsy have an underlying genetic predisposition attributed to HLA DQB1*0602 gene. This variant has been linked increased propensity for sleepi...

Sleep is widely recognized as essential, but without a clear singular function. Inadequate sleep impairs cognition, metabolism, immune function, and many other processes. Work in genetic model systems has greatly expanded our understanding of basic sleep neurobiology as well as introduced new concepts for why we sleep. Among these is an idea with its roots in human work nearly 50 years old: sle...

Background. There are limited data on sleep duration and diabetes from developing countries. We therefore examined the relationship between reported hours of sleep, diabetes prevalence and glucose control in Jamaican adults. Methods. Data on reported hours of sleep and diabetes (based on glucose measurement and medication use) from a national survey of 15-74-year-old Jamaicans were analyzed. Re...

A 47-year-old male patient with alcohol-related cirrhosis presented to the liver clinic complaint of repeated episodes hepatic encephalopathy (HE) manifested as a disturbance in sleep pattern, hypersomnia, impaired memory, mental confusion, and drowsiness (West Haven grade II/III). On evaluation, had Child-Pugh score 6 (CTP-A), hyperammonemia (>200 µg/dL), small low-risk esophageal varices, spl...

Here is reported an unusual case of substance dependence with buprenorphine, mephentermine, & promethazine. This combination taken through intramuscular route produced a relatively mild & delayed abstinence syndrome with features viz. increased sleep and appetite in the patients. The neurophysiological basis for use of this rare form of additive (mephentermine) with buprenorphine is speculated.

Objectives To determine the interaction of age and habitual sleep duration in predicting cognitive performance in a large sample of participants aged 15 to 89 years. Methods This study is a cross-sectional analysis of performance data gathered between January 2012 and September 2013. First-time players (N = 512823) of three internet cognitive training games measuring processing speed, working...

Sleepiness is the condition where for some reason fails to go into a sleep state and will have difficulty in remaining awake even while carrying out activities. Sleep restriction occurs when an individual fails to get enough sleep due to high work demands. The mechanism between sleep restriction and underlying brain physiology deficits is not well assumed. The objective of the present study was...