نتایج جستجو برای: hyperinsulinemia
تعداد نتایج: 3911 فیلتر نتایج به سال:
We hypothesized that insulin alters plasma free fatty acid (FFA) trafficking into intramyocellular (im) long-chain acylcarnitines (imLCAC) and triglycerides (imTG). Overnight-fasted adults (n = 41) received intravenous infusions of [U-¹³C]palmitate (0400-0900 h) and [U-¹³C]oleate (0800-1400 h) to label imTG and imLCAC. A euglycemic-hyperinsulinemic (1.0 mU·kg fat-free mass⁻¹·min⁻¹) clamp (0800-...
Cerebral insulin receptors play an important role in regulation of energy homeostasis and development of neurodegeneration. Accordingly, type 2 diabetes characterized by insulin resistance is associated with an increased risk of developing Alzheimer's disease. Formation of neurofibrillary tangles, which contain hyperphosphorylated tau, represents a key step in the pathogenesis of neurodegenerat...
Insulin modulates the biochemical pathways controlling lipid uptake, lipolysis and lipogenesis at multiple levels. Elevated insulin levels are associated with obesity, and conversely, dietary and pharmacological manipulations that reduce insulin have occasionally been reported to cause weight loss. However, the causal role of insulin hypersecretion in the development of mammalian obesity remain...
Data defining the isolated effect of insulin on whole body protein and glucose metabolism in cancer patients are limited. Ten normal volun teers (controls), age 55 ±3 years (mean ±SEM); 8 cancer patients, age 61 ±3years, weight loss 2 ±1% (CANWL); and 8 cancer patients, age 55 ±2 years, weight loss 18 ±2% (CAWL), were studied in the postabsorptive state. Whole body leucine kinetics were d...
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