objectives: hypericum perforatum l. is a medicinal plant containing many polyphenolic compounds, ‎including flavonoids and phenolic acids with antidepressant and anti-inflammatory properties. ‎this study was investigated the effects of hypericum perforatum extract (hpe) on immunity, ‎body weight (bw), and spleen index (si) in rats.‎ materials and methods: a total of 24 wistar male rats were ran...

A standardised 50% aqueous ethanolic extract of the Indian variety of Hypericum perforatum (IHp) was examined for its putative anti-inflammatory and analgesic activity at the doses of 100 and 200 mg/kg, po. The experimental paradigms used were carrageenan induced pedal edema and cotton pellet induced granuloma for anti-inflammatory activity, whereas the tail flick, hot plate and acetic acid ind...

Hypericum perforatum (St John's wort) is a well known medicinal plant used in many pharmaceutical formulations and its main active compound is hypericin. The purpose of our study was to examine the plasma level of hypericin upon long term mice treatment with Hyperici herba extract. A reversible hyperthermia was recorded upon 2 hours of the extract administration, both in males and females. Hype...

Herb-induced liver injury (HILI) has recently attracted attention due to increasing reports of hepatotoxicity associated with use of phytotherapeutics. Here, we present data on HILI from the Berlin Case-Control Surveillance Study. The study was initiated in 2000 to investigate the serious toxicity of drugs including herbal medicines. Potential cases of liver injury were ascertained in more than...

Homeopathic remedies are produced by potentising, that is, the serial logarithmic dilution and succussion of a mother tincture. Techniques like ultraviolet spectroscopy, nuclear magnetic resonance, calorimetry, or thermoluminescence have been used to investigate their physical properties. In this study, homeopathic centesimal (c) potencies (6c to 30c) of copper sulfate, Hypericum perforatum, an...

Hypericum perforatum (St. John's wort) is well-established for its antidepressant activity throughout the world and also various other species within this genus are used in different folk medicines. Hyperforin of St. John's wort inhibited growth of cancer cell lines and the use of hypericin (another compound of H. perforatum) in cancer photodynamic therapy is proposed. Therefore, we investigate...

Mary Ellen Avery Treasurer Francisco J. Ayala Richard S. Nicholson Robert A. Frosch Executive Officer John Abelson Frederick W. Alt Don L. Anderson Stephen J. Benkovic David E. Bloom Floyd E. Bloom Henry R. Bourne James J. Bull Kathryn Calame C. Thomas Caskey Dennis W. Choi John M. Coffin Bruce F. Eldridge Paul T. Englund Richard G. Fairbanks Douglas T. Fearon Harry A. Fozzard Victor R. Fuchs T...