Frederick John Poynton was born at Kelston rectory, Bath, in 1869. On leaving Marlborough College he started his medical education at University College, Bristol, and continued it at St. Mary's Hospital where he won a scholarship in Anatomy and Physiology. He qualified in 1893, and rapidly showed the absorbing interest in children which largely determined his medical career. A disciple of Chead...

Based on knowledge from traditional Arab herbal medicine, this in vitro study aims to examine the anti-inflammatory mechanism of Hypericum triquetrifolium by measuring the expression and release of pro-inflammatory cytokines, tumor necrosis factor-α (TNF-α) and interleukine-6 (IL-6), and inducible nitric oxide synthase (iNOS) in human monocytic cells, THP-1. The effects were assessed by measuri...

Reverse transcription-quantitative real-time PCR (RT-qPCR) is a widely used technique for gene expression analysis. The reliability of this method depends largely on the suitable selection of stable reference genes for accurate data normalization. Hypericum perforatum L. (St. John's wort) is a field growing plant that is frequently exposed to a variety of adverse environmental stresses that can...

over production of uric acid by xanthine oxidase (xo) causes gout. xo inhibitors for example allopurinol are the most important available anti gout drugs. medicinal herbs are available natural sources that may be useful for the treatment of gout. in this study the inhibitory activity of aqueous extracts of matricaria chamomilla l., hypericum perforatum l., fraxinus excelsior l., zea mays l., tr...

Model studies of the influence lectin-containing extracts medicinal plants St. John's wort (Hypericum perforatum L.), common yarrow (Achillea millefolium marigold (Calendula officinalis L.) and dwarf evergreen (Helichrysum arenarium (L.) Moench.) on growth development wheat, oat, barley rye at beginning their ontogenesis. They testify to specificity action in relation model objects, which is pr...

In the present work we carried out a phytochemical and biological investigation on three endemic Hypericum species, i.e. Hypericum thymbrifolium, Hypericum spectabile and Hypericum pseudolaeve from Anatolia in order to discover new sources of natural compounds for the treatment of inflammatory and neurodegenerative disorders. HPLC-DAD analysis indicated that two naphthodianthrones (pseudohyperi...

Six new polycyclic polyprenylated acylphloroglucinols (PPAPs), named hyperisampsins H-M (1-6), were isolated from the aerial parts of Hypericum sampsonii, together with five known analogs (7-11). The structures of 1-6 were established by extensive spectroscopic analyses, including HRESIMS and NMR. In addition, the absolute configurations of these new compounds were determined by electronic circ...

OBJECTIVES The John Henryism (JH) hypothesis suggests that, under adverse social and economic conditions, high-effort coping styles that reflect hard work and determination may contribute to elevated blood pressure. Results from tests of this hypothesis have been mixed, with variations by region, urban versus rural areas, race, gender, and age. The majority of studies reporting that socioeconom...

ss Open Acce Proceedings Genetic Analysis Workshop 15: gene expression analysis and approaches to detecting multiple functional loci Heather J Cordell*1, Mariza de Andrade2, Marie-Claude Babron3, Christopher W Bartlett4, Joseph Beyene5, Heike Bickeböller6, Robert Culverhouse7, L Adrienne Cupples8, E Warwick Daw9, Josée Dupuis8, Catherine T Falk10, Saurabh Ghosh11, Katrina A Goddard12, Ellen L G...

The relationship between law and morality represents a major theme in jurisprudence and is the subject-matter of this article. I shall focus on the use of the criminal law to enforce morality and, in particular, I shall consider whether an identifiable line can be drawn between moral standards that may properly be the subject of legal enforcement and those that may not. This issue was, of cours...