Hyperhomocysteinemia is an independent risk factor for cardiovascular disorders. Elevated plasma homocysteine (Hcy) concentration is associated with other cardiovascular risk factors. We previously reported that Hcy stimulated cholesterol biosynthesis in HepG2 cells. In the present study, we investigated the underlying mechanisms of Hcy-induced hepatic cholesterol biosynthesis in an animal mode...

BACKGROUND Hyperhomocysteinemia is a cardiovascular disease (CVD) risk factor. We determined plasma homocysteine (Hcy) reference values at optimized vitamin status and investigated their influence on the prevalence of hyperhomocysteinemia in healthy adults. Results were compared with those obtained using European Concerted Action Project (ECAP) cutoff values. METHODS Healthy adults (n = 101) ...

BACKGROUND Microalbuminuria (MA) is a strong predictor of cardiovascular disease, but its causes are incompletely understood. Hyperhomocysteinemia is a recently recognized risk factor for cardiovascular disease independent of established risk factors. It is not known whether hyperhomocysteinemia is associated with MA, and thus could be a possible cause of microalbuminuria. METHODS We studied ...

A high serum total homocysteine (tHcy) level is an independent risk factor for cardiovascular disease. Because it is not known whether the strength of the association between hyperhomocysteinemia and cardiovascular disease is similar for peripheral arterial, coronary artery, and cerebrovascular disease, we compared the three separate risk estimates in an age-, sex-, and glucose tolerance-strati...

To clarify the relationship between dietary choline level and plasma homocysteine concentration, the effects of choline deprivation on plasma homocysteine concentration and related variables were investigated in rats fed a standard (25%) casein (25C) diet or standard soybean protein (25S) diet. Using the 25S diet, the time-dependent effect of choline deprivation and the comparative effects of t...

Hyperhomocysteinemia has been identified as a risk factor for coronary artery disease (CAD).1-9 In a nested case control study in Norway on 21,826 subjects in general population, hyperhomocysteinemia was clearly identified as an independent risk factor for CAD with no threshold level.9 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the methylation of homocysteine and its role in...

INTRODUCTION Anemia and hyperhomocysteinemia are risk factor of mortality of patients on dialysis. This study was conducted to assess the relationship of hemoglobin and homocysteine levels and mortality of patients on hemodialysis. MATERIALS AND METHODS Fifty patients on hemodialysis and 20 healthy individuals were enrolled in the study. Blood samples were drawn for measurement of hematologic...

BACKGROUND Before the advent of highly active antiretroviral therapy (HAART), 20% and 10% of HIV-infected patients had low vitamin B-12 and red blood cell folate (RBCF) concentrations, respectively. However, few patients had real vitamin B-12 deficiency. OBJECTIVE We evaluated the prevalence of low vitamin B-12 and RBCF concentrations in HIV-infected patients receiving HAART and the usefulnes...

The endotelio- and cardioprotective effects of vitamin B6 (2 mg/kg) folic acid (0.2 upon modeling methionine-induced hyperhomocysteinemia via methionine intragastric administration at a dose 3 g/kg were studied. It was shown that the combined use allows on background significant reduction in homocysteine concentrations normalizing endothelial dysfunction coefficient parameters maximum left vent...

Background: Metabolic syndrome (MetS) is a major risk factor for cardiac mortality and morbidity. Hyperhomocysteinemia folic acid are related with MetS. Both MetS hyperhomocysteinemia adversely affect heart rate variability (HRV). Objectives: To assess the relationship of vitamin B12, homocysteine levels HRV in female patients. Methods: This cross sectional study was carried out on 40 patients ...