نتایج جستجو برای: hydroxypropyl b cyclodextrin

تعداد نتایج: 907447  

Journal: :Brazilian Journal of Pharmaceutical Sciences 2022

The main purpose of this work was to compare the effects four preparation methods on TFLX/HP-β-CD inclusion complex. different complex were investigated by SEM, DSC, PXRD, FT-IR and 1H NMR. All characterization information indicated that could cause interaction between TFLX HP-β-CD, but prepared solvent evaporation has more reaction sites. Phase solubility experiments demonstrated spontaneous. ...

Journal: :Molecular Simulation 2021

In the present work, preferential binding mode of Fluorometholone (FLU) drug into nanopores two cyclodexterins, b-cyclodextrin (b-CD) and sulfobutylether-b-cyclodextrin (SEB-b-CD), are theoretically investigated using density functional theory (DFT), Docking, molecular dynamics (MD) simulation MM-PBSA free energy calculations. The computational results reveal that hydrogen bonds (HBs) van der W...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2009
Ying Dong Shook-Fong Chin Elvin Blanco Erik A Bey Wareef Kabbani Xian-Jin Xie William G Bornmann David A Boothman Jinming Gao

PURPOSE beta-Lapachone (ARQ 501, a formulation of beta-lapachone complexed with hydroxypropyl-beta-cyclodextrin) is a novel anticancer agent with selectivity against prostate cancer cells overexpressing the NAD(P)H:quinone oxidoreductase-1 enzyme. Lack of solubility and an efficient drug delivery strategy limits this compound in clinical applications. In this study, we aimed to develop beta-lap...

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