The synthetic retinoid, N-(4-hydroxyphenyl)retinamide (4-HPR; Fenretinide), is a cancer chemopreventive and antiproliferative agent whose mechanism of action is unknown. 4-HPR alone is a poor inducer of differentiation of HL-60 cells compared to all-trans-retinoic acid (RA). Here, we found that combinations of 4-HPR and RA synergistically induced differentiation of HL-60 cells. In addition, 4-H...

Great attention has been paid to the increasing amount of municipal sludge generated from wastewater treatment plants due to its potential risks to the surrounding environment. The municipal sludge, which mainly composed of polysaccharides, proteins as well as abundant groups of microorganisms, has been proved to be a promising biological material for hydrogen production by anaerobic fermentati...

Breast cancer most frequently metastasizes to bone causing decreased quality of life and morbidity. Since current treatments are palliative, strategies to prevent bone metastases in breast cancer patients are required. There is substantial evidence indicating that high levels of nitric oxide (NO) suppress tumor growth and metastasis in vivo. We hypothesize that agents that produce high concentr...

⎯Hydrogen, oxygen, and hydrogen peroxide have been measured downstream of an atmospheric pressure humid argon dielectric barrier discharge. The yield of the three species was studied as a function of the discharge power and gas flow rate. Hydrogen peroxide was measured after dissolution into water downstream of the discharge, while hydrogen and oxygen were measured in the gas phase. The product...

In methanogenic microbial electrolysis cells (MMCs), CO2 is reduced to methane using a methanogenic biofilm on the cathode by either direct electron transfer or evolved hydrogen. To optimize methane generation, we examined several cathode materials: plain graphite blocks, graphite blocks coated with carbon black or carbon black containing metals (platinum, stainless steel or nickel) or insolubl...

In this study, the feasibility of biohydrogen production from enzymatic hydrolysis of food waste was investigated. Food waste (solid-to-liquid ratio of 10%, w/v) was first hydrolyzed by commercial glucoamylase to release glucose (24.35 g/L) in the food waste hydrolysate. Then, the obtained food waste hydrolysate was used as substrate for biohydrogen production in the batch and continuous (conti...

An experimental matrix consisting of reactor hydraulic retention time (HRT) and glucose loading rate was tested to understand the effect of organic loading on H2 production in chemostat reactors. In order to vary the glucose loading rate over a range of 0.5-18.9 g/h, the glucose concentration in the feed was varied from 2.5 to 10 gCOD/L under conditions where the HRT varied from 1 to 10 h (30 d...