A direct polarographic method for the determination of chlorpheniramine maleate in pharmaceutical preparations had been developed. The method was based on the reduction of chlorpheniramine maleate in an acidic medium (pH 1.2-4.0). The effect of pH on the polarographic wave was investigated by recording d.c. polarograms in various supporting electrolytes. The calibration graphs were rectilinear ...

1. Conditions favouring the condensation of o-phenylenediamine with alpha-oxo acids to form substituted quinoxalines have been investigated. The best yields (85-100%) are obtained by incubation of the reagents in 2m-hydrochloric acid. Substitution of acetic acid for hydrochloric acid, or of halogen-substituted 1,2-diaminobenzenes for phenylenediamine, increases the initial rate of reaction, but...

The pepsin was obtained in the form of a 5 per cent solution in glycerol (1 cc. containing 50 rag. of pepsin). I t was diluted tenfold before use with 0.01 s hydrochloric acid (pH 2). 5 ram. 8 were blown out of a calibrated micropipette on the surface of the water in a Langmuir tray according to the method which we have used for several years. Effect of pH.--The effect of pH on the amount of th...

Pantoprazole is converted to its active form in the acidic canaliculi of the parietal cells when it inhibits the H, K-ATPase enzyme, i.e. the final stage in the production of hydrochloric acid in the stomach. The inhibition is dose-dependent and affects both basal and stimulated acid secretion. In most patients, freedom from symptoms is achieved in 2 weeks. As with other proton pump inhibitors ...

Since 1836, when Theodor Schwann signalized the presence in gastric juice of the proteolytic ferment which he was the first to designate as pepsin, a large number of attempts have been made to isolate it in a pure form to determine its chemical nature and its ultimate physiological properties. In a large majority of these, and, especially, all those made before 1895, except that of Brticke (I),...

The paper considers the modeling of CO 2 -corrosion on chromium-containing steels 1-5%. Study protective properties a layer corrosion products with chromium content 1-5% and effect periodic hydrochloric acid treatments.

The effect of aspirin (acetylsalicylic acid) ingestion on occult gastrointestinal blood loss has been studied in patients with treated Addisonian pernicious anaemia and proved achlorhydria and in control patients able to secrete hydrochloric acid. A highly significant increase in gastrointestinal blood loss (1.9 ml./day of treatment) occurred with aspirin ingestion in the achlorhydric patients....

A trace level concentration of osmium(VIII) has been quantitatively extracted from 1.0 M hydrochloric acid with 0.087 M N-n-octylaniline as a stationery phase on silica gel. Osmium(VIII) has been eluted with 5.5 M, 25 mL hydrochloric acid and determined by spectrophotometric method. Various parameters influencing the extraction, such as acid concentration, reagent concentration and flow rate ha...

Since 1836, when Theodor Schwann signalized the presence in gastric juice of the proteolytic ferment which he was the first to designate as pepsin, a large number of attempts have been made to isolate it in a pure form to determine its chemical nature and its ultimate physiological properties. In a large majority of these, and, especially, all those made before 1895, except that of Brticke (I),...