The influence of hypertension and of treatment with some dihydropyridine-type Ca(2+) channel blockers and with the nondihydropyridine-type vasodilator hydralazine on the morphology of kidney was investigated in 26-week-old spontaneously hypertensive rats (SHR) and in age-matched Wistar-Kyoto rats. Fourteen-week-old SHR were treated for 12 weeks with a nonhypotensive dose of lercanidipine or wit...

The hypotensive efficacies of two vasodilators, hydralazine and minoxidil, were assessed as these drugs were used individually in combination with beta-adrenergic blockade and diuretics in 11 hypertensive patients in whom elevated blood pressure had not been adequately controlled previously by other antihypertensive therapy. Control supine blood pressure fell from 191/128 mm Hg on propranolol a...

The effect of afterload reduction was studied in a group of patients who remained breathless or tired after permanent ventricular pacing. Haemodynamic measurements were made before and after giving hydralazine 20 mg intravenously using a triple lumen thermodilution catheter and cuff blood pressure recordings during ventricular pacing at the standard rate of 71/min or an increased rate of 88/min...

This study was designed to test the hypothesis that vasodilator drugs can enhance selective heating of solid tumors by producing a favorable redistribution of blood flow between tumor and normal tissues. Subcutaneous transmissible venereal tumor implants were heated by inductive diathermy using Helmholtz coils in 8 dogs. The temperature rise in tumor and adjacent muscle was measured before and ...

BACKGROUND & AIMS Drug-induced liver injury (DILI) has features similar to those of other liver diseases including autoimmune hepatitis (AIH). We aimed to characterize the clinical and autoimmune features of liver injury caused by nitrofurantoin, minocycline, methyldopa, or hydralazine. METHODS We analyzed data from 88 cases of DILI attributed to nitrofurantoin, minocycline, methyldopa, or hy...

SUMMARY Although vasodilator drugs cause haemodynamic improvement at rest, their effect on the overall exercise response is uncertain. Nine patients with severe diuretic dependent cardiac failure were studied before and during upright bicycle exercise, after the double blind administration of equi-hypotensive doses of hydralazine (H) 75 mg, prazosin (Pr) 3 mg, and placebo (P1). The ventilatory ...

When increased in vascular tissues, angiotensin-converting enzyme 2 (ACE2), a carboxypeptidase that hydrolyzes angiotensin II to angiotensin-(1-7), may augment the growth inhibitory and vasodilatory effects of the heptapeptide. We investigated the regulation of ACE2 and angiotensin-(1-7) expression in aortas and carotid arteries of 12-wk-old male spontaneously hypertensive rats (SHR) by determi...

Drug-induced lupus (DIL) is an autoimmune condition where a drug exposure leads to the development of idiopathic systemic erythematosus (SLE) like clinical features in genetically susceptible individual, but typically without major organ-threatening complications. The mechanism disease involved DIL remain uncertain. first report link with drug- sulfadiazine dates back 1945. Morrow et al 1953 de...

Supine and upright hemodynamic measurements were performed in 10 patients with chronic congestive heart failure, before and during vasodilator therapy with hydralazine and isosorbide dinitrate. This combination of drugs produced significant improvement in supine hemodynamic measurements, with the pulmonary capillary wedge pressure decreasing from 26 +/- 5 to 18 +/- 5 mm Hg (mean +/- SD, p less ...