Mouse chromosome 12 encodes the heavy chains of immunoglobulins (Igh), a family of T cell surface molecules, and a tumor antigen that may be homologous to immunoglobulins. To refine and extend the genetic map of this chromosome, a procedure has been developed to isolate chromosome 12-specific DNA fragments from a somatic cell hybrid carrying the chromosome on a Chinese hamster background. Five ...

‘l’l~e SWYW EcoKI restriction endonuclease cleavage sites in bacteriophage P%d DNA have been mapped. The cleavage site map of circularly permut.ed P22 linear DNA is a circle. The positions of EcoRI sites in the early region of the P22 genomc were determined by comparing products of EcoRI digestion of maturtx liaear P22 chromosomes with the EcoRI cleavage fragments of DNA of three XimmP22 hybrid...

Comparative maps between ruminant species and humans are increasingly important tools for the discovery of genes underlying economically important traits. In this article we present a primary linkage map of the deer genome derived from an interspecies hybrid between red deer (Cervus elaphus) and Père David's deer (Elaphurus davidianus). The map is approximately 2500 cM long and contains >600 ma...

In order to study the ability of coupled neural oscillators to synchronize in the presence of intrinsic as opposed to synaptic noise, we constructed hybrid circuits consisting of one biological and one computational model neuron with reciprocal synaptic inhibition using the dynamic clamp. Uncoupled, both neurons fired periodic trains of action potentials. Most coupled circuits exhibited qualita...

Crossing experiments indicate that hybrid sterility barriers frequently have developed within diploid, circumpolar plant species of the genus Draba. To gain insight into the rapid evolution of postzygotic reproductive isolation in this system, we augmented the linkage map of one of these species, D. nivalis, and searched for quantitative trait loci (QTLs) associated with reproductive isolation....

We propose a method for a parallel implementation of the Self-Organizing Map (SOM) algorithm, widely used in data-mining. We call this method Hybrid in the sense that it combines the advantages of the common network-partition and data-partition approaches, and is particularly effective when dealing with large maps. Based on the fact that a global topological ordering of the map is achieved in a...

Several strategies in phase retrieval are unified by an iterative "difference map" constructed from a pair of elementary projections and three real parameters. For the standard application in optics, where the two projections implement Fourier modulus and object support constraints, respectively, the difference map reproduces the "hybrid" form of Fienup's input-output map when a particular choi...

We report the physical mapping of porcine expressed sequence tags (ESTs) from anterior pituitary clones isolated by differential display PCR in a study using lines selected for reproduction. These ESTs were mapped using a somatic cell hybrid panel (SCHP) and a radiation hybrid panel (IMpRH) as follows (SCHP position, nearest marker on the RH map): SPARCL1 (8q23-q27, SSP1); ATF4 (5p11-p15, AC02)...

An intelligent tutoring system plays vital role in education and its importance is constantly increasing, meanwhile the key challenge in the teaching learning process is assessing students’ learning efficiently. In this paper, a hybrid assessment based-on ACT-R cognitive learning theory, combining ontology knowledge map with skills is proposed. In order to assess how well students master knowle...

Systems with impulse effects form a special class of hybrid systems that consist of an ordinary, time-invariant differential equation (ODE), a co-dimension one switching surface, and a re-initialization rule. The exponential stability of a periodic orbit in a C-nonlinear system with impulse effects can be studied by linearizing the Poincaré return map around a fixed point and evaluating its eig...