Photoacoustic imaging (PAI) is an emerging noninvasive and inexpensive bioimaging modality, which has stimulated a wide interest in recent years for cancer theranostics. Hybrid nano- microgels have been designed as protective carriers to incorporate PAI contrast agents due their biocompatibility biodegradability, high loading capacity, versatile surface chemistry, stimuli-responsive properties....

The written report (or its electronic counterpart) is the primary mode of communication between the physician interpreting an imaging study and the referring physician. The content of this report not only influences patient management and clinical outcomes but also serves as legal documentation of services provided and can be used to justify medical necessity, billing accuracy, and regulatory c...

Increasing the space-bandwidth product of an imaging system will lead to a complex and expensive optical system. Techniques exist to simplify imaging systems. We propose the use of a hybrid imaging system using pupil phase modulation. Based on the reconstructed image's mean-squared error, we compute how this error is affected under various third-order aberrations. We determine the best cubic ph...

Ultrasound-modulated optical tomography is a developing hybrid imaging modality that combines high optical contrast and good ultrasonic resolution for imaging soft biological tissue. We developed a photorefractive-crystal-based, time-resolved detection scheme with the use of a millisecond long ultrasound burst to image both the optical and the mechanical properties of biological tissues, with i...

Concrete petrography is used to assess damaged concrete in order to determine the probable mechanism of damage. However, using traditional petrographic analyses, it is often difficult to say what mechanisms caused the crack damage, since many deterioration mechanisms produce cracks. This article describes a hybrid imaging-finite element modelling technique that can be used to help determine the...

We investigated noninvasive procedures by hybrid imaging to assess the sites of active or inactive hematopoiesis in patients with primary myelofibrosis (PMF). To this end, we used two radionuclides, technetium 99m ((99m) Tc) and indium 111-chloride ((111) In-Cl3 ), coupled with single-photon emission tomography/computed tomography (SPECT/CT). We studied five patients with PMF and one with secon...

An advantage of fluorescence methods over other imaging modalities is the ability to concurrently resolve multiple moieties using fluorochromes emitting at different spectral regions. Simultaneous imaging of spectrally separated agents is helpful in interrogating multiple functions or establishing internal controls for accurate measurements. Herein, we investigated multimoiety imaging in the co...

Background—Computed tomography (CT) is increasingly used to detect coronary artery disease, but the evaluation of stenoses is often uncertain. Perfusion imaging has an established role in detecting ischemia and guiding therapy. Hybrid positron emission tomography (PET)/CT allows combination angiography and perfusion imaging in short, quantitative, low-radiation-dose protocols. Methods and Resul...

Hybrid imaging is becoming a popular technology in nuclear medicine. We have evaluated the added value of an integrated SPECT/low-dose multislice CT over conventional planar/SPECT nuclear imaging. Phantom and clinical studies were performed on the InfiniaTM HawkeyeTM 4 slice (HWK-4) with an upgraded software package (Xeleris 2.05v) from GE Heatlthcare to assess 1) the benefit of CT for contrast...