BACKGROUND The number of dementia patients has increased worldwide, with an estimated 13.7 million dementia patients in the Asia Pacific region alone. This number is expected to increase to 64.6 million by the year 2050. DISCUSSION As a result of advances in research, there several pharmacological therapies available for the treatment of dementia patients. However, current treatments do not s...

Purpose Cromakalim prodrug 1 (CKLP1) is a water-soluble ATP-sensitive potassium channel opener that has shown ocular hypotensive properties in ex vivo and in vivo experimental models. To determine its mechanism of action, we assessed the effect of CKLP1 on aqueous humor dynamics and in combination therapy with existing ocular hypotensive agents. Methods Outflow facility was assessed in C57BL/...

The Eysenckian PEN System of personality (Eysenck 1991; Eysenck and Eysenck 1985), comprising the superfactors Psychotidsm (P), Extraversion (E), and Neuroticism (N), is used äs a means to locate different humorrelated traits. A sample of 159 German adults answered a sample of temperamental traits relating to the PEN System äs well äs five humorrelated questionnaires. The temperament inventorie...

Shortly before his death in 1995, Kenneth B. Schwartz, a cancer patient at Massachusetts General Hospital (MGH) founded The Kenneth B. Schwartz Center at MGH. The Schwartz Center is a nonprofit organization dedicated to supporting and advancing compassionate health care delivery, which provides hope to the patient and support to caregivers and encourages the healing process. The center sponsors...

PURPOSE To investigate copy numbers of cytomegalovirus (CMV) in CMV retinitis patients during ganciclovir treatment using real-time polymerase chain reaction (PCR). METHODS Thirteen aqueous humor samples obtained from 6 patients with clinically diagnosed CMV retinitis were analyzed. As controls, aqueous humor samples were obtained at the time of surgery from patients with senile cataracts. ...

1. Introduction Aqueous humor, which acts to supply metabolic needs of intraocular structures, is produced constantly by the ciliary body of the equine eye. The fluid must also drain constantly from the eye through the iridocorneal and uveoscleral outflow pathways. Obstruction of this outflow of fluid can be the result of an abnormally developed drain (i.e., primary glaucoma) or through damage ...

By using a highly sensitive and specific radioimmunoassay and the slot-blot technique, transferrin was quantified in fresh samples of aqueous humor from patients with primary open-angle glaucoma (POAG, n = 36) or secondary glaucoma (SG, n = 18). The levels were compared with those in aqueous humor obtained from age-matched patients without glaucoma (n = 33) and in primary and secondary aqueous ...

In this study, the authors explored the use of positive, negative, and avoiding humor in 2 types of situations by individuals in romantic relationships. Participants (N = 154) rated their frequency of humor use in either a typical conflict scenario with their partner or a typical pleasant event. Participants also indicated their overall degree of romantic relationship satisfaction. Hierarchical...

Cognitive distortions are negative biases in thinking that are theorized to represent vulnerability factors for depression and dysphoria. Despite the emphasis placed on cognitive distortions in the context of cognitive behavioural theory and practice, a paucity of research has examined the mechanisms through which they impact depressive symptomatology. Both adaptive and maladaptive styles of hu...