introduction: the human skin is an active medium from the optical point of view. therefore, the diagnostic and therapeutic techniques employing light are increasing. current optical techniques are based on the measurement of the intensity of reflected absorbed or backscattered light from or within skin. studies have shown that biological tissues, and in particular skin, demonstrate polarization...

ATP-binding cassette (ABC) transporters transport a variety of substrates across cellular membranes coupled with hydrolysis of ATP. Currently 49 ABC transporters consisting of seven subfamilies, ABCA, ABCB, ABCC, ABCD, ABCE, ABCF, and ABCG, have been identified in humans and they are extensively expressed in various tissues. Skin can develop a number of drug-induced toxicities' such as Stevens-...

Skin morphology of the Clawn miniature pig (CMP) was investigated at the axilla, medial thigh, back and loin. The mean thickness of the epidermis (excluding the corneal layer), the mean number of layers of keratinocytes comprising the epidermis and the mean height of keratinocytes were assessed morphometrically. When observed under a light microscope, the skin of the CMP resembled human skin. M...

BACKGROUND Most identified drug transporters belong to the ATP-binding cassette (ABC) and solute carrier (SLC) families. Recent research indicates that these transporters play an important role in the absorption, distribution and excretion of drugs, and are involved in clinically relevant drug-drug interactions for systemic drugs. However, very little is known about the role of drug transporter...

Understanding the interactions of nanoparticles (NPs) with skin is important from a consumer and occupational health and safety perspective, as well as for the design of effective NP-based transdermal therapeutics. Despite intense efforts to elucidate the conditions that permit NP penetration, there remains a lack of translatable results from animal models to human skin. The objectives of this ...

Takao Someya et al. report the development of a f lexible, electronic skin capable of detecting both pressure and temperature, an advance that may provide robots with a humanlike sense of touch. The research team previously developed artificial skin that could sense pressure but lacked the elasticity and other characteristics of human skin. To improve the artificial skin material, Someya et al....

The skin locally synthesizes significant amounts of sexual hormones with intracrine or paracrine actions. The local level of each sexual steroid depends upon the expression of each of the androgen- and estrogen-synthesizing enzymes in each cell type, with sebaceous glands and sweat glands being the major contributors. Sebocytes express very little of the key enzyme, cytochrome P450c17, necessar...

Rendering realistic human skin is not a trivial task. It means dealing with light diffusion in a multi-layered material, where multiple subsurface scattering events take place. Great care must be taken when simulating its appearance, to avoid an unnatural, waxy look. Recent works in the field of computer graphics have provided us with the ability to accurately render human skin, both off-line a...