Background: Our study aimed to establish a clinically practical and reliable prognostic nomogram based on the important factors predict prognosis of patients with lung metastatic renal cell carcinoma (RCC).

Neuroendocrine tumor of the lung is classified into four subtypes according to the recent World Health Organization Classification: typical carcinoid, atypical carcinoid, small cell carcinoma, and large cell neuroendocrine carcinoma (LCNEC) [1]. LCNEC is a relatively rare histopathological subtype of lung carcinoma, which accounts for approximately 3% of all lung carcinomas [1]. It has been wel...

Siberian ginseng (Eleutherococcus senticosus) is used primarily as an adaptogen herb and also for its immune stimulant properties in Western herbal medicine. Another closely related species used in East Asian medicine systems i.e. Kampo, TCM (Manchuria, Korea, Japan and Ainu of Hokkaido) and also called Siberian ginseng (Acanthopanax senticosus) also displays immune-stimulant and anti-cancer pr...

Plant cell cultures from cloudberry (CL), lingonberry (LI), stone berry (ST), arctic bramble (AB), and strawberry (SB) were studied in terms of their polyphenol carotenoid composition, antioxidant activity, antihemolytic activity cytotoxicity effects on cancerous cells. High-resolution mass spectrometry data showed that LI, presented the highest contained contents flavones, phenolic acids, lign...

Recently, we developed a nutritionally optimal medium for rapid clonal growth (greater than 1 population doubling/day) of normal human bronchial epithelial (NHBE) cells. Adding fetal bovine or adult human blood-derived serum to this medium depresses the clonal growth rate of NHBE cells in a dose-dependent fashion. In contrast, 10 representative lines of human lung carcinomas either replicate po...

The retinoic acid receptor type IB (RARJ~) complementary DNA from a small cell tumor line was amplified, sequenced, and found to be homologous to the murine RAR~I1. Seventeen lung tumor lines were analyzed. Five of seven small cell lung carcinoma lines expressed RARI~I, but only one other line (epidermoid) expressed the isoform, and this was at trace levels. Two other epidermoid lines, as well ...

There are some reports on the lignan constituents of Linum spp. In this study, we investigated the cyototoxicity of Linum spp. in vitro cultures for the first time. If they show significant cytotoxic activity, they will be valuable candidates for isolation of cytotoxic compounds in large scale from them by tissue culture technology. In our study, we chose normal root, hairy root and calli cultu...

The features of Hypertrophic pulmunary osteoarthropathy (HPOA) on radionuclide bone scintigraphy have been well described in case reports and small series of patients. The aim of this study was to investigate prospectively the prevalence and distribution of HPOA in a large series of patients with carcinoma of the lung. Two hundred and eleven patients aged 31-89 years (average age 66 years...

The aim of the present study was to investigate the effect of rutin treatment on the expression of glycogen synthase kinase (GSK)-3β and tumor necrosis factor (TNF)-α in A549 human lung carcinoma cells. The A549 cells were divided into control, cisplatin and rutin (low, middle and high) groups. ELISA and western blot analysis of TNF-α expression, 4',6-diamino-2-phenylindole (DAPI) staining and ...