It was first predicted in 1988 that there may be an Open Reading Frame (ORF) on the negative strand of Human Immunodeficiency Virus type 1 (HIV-1) genome could encode a protein named AntiSense Protein (ASP). In spite some controversy, reports began to emerge years later describing detection HIV-1 antisense transcripts, presence ASP transfected and infected cells, existence immune response targe...

ObjectivesTo demonstrate the successful use of pharmacogenomic testing to specifically tailor antifungal treatment phenotype a patient with human immunodeficiency virus (HIV) and disseminated histoplasmosis who had clinical progression while on itraconazole subsequently insufficient therapeutic drug levels voriconazole.Case summaryWe present case HIV persistently elevated serum Histoplasma caps...

BACKGROUND Human primary monocytes are refractory to infection with the human immunodeficiency virus 1 (HIV-1) or transduction with HIV-1-derived vectors. In contrast, efficient single round transduction of monocytes is mediated by vectors derived from simian immunodeficiency virus of sooty mangabeys (SIVsmmPBj), depending on the presence of the viral accessory protein Vpx. METHODS AND FINDIN...

It is generally accepted that human immunodeficiency virus (HIV) is the etiologic agent of the acquired immunodeficiency syndrome and related diseases. In this report, we demonstrate the antiviral effect of nucleoside analogs 2',3'-didehydro-2',3'-dideoxythymidine (DHT) and 2',3'-didehydro-2',3'-dideoxycytidine (DHC) by using human T-cell lymphotropic virus type I-carrying MT-4 cells, which are...

intestinal pseudo-obstruction is a condition in which the intestine’s ability to push food through is reduced. it often leads to the dilation of the various parts of the bowel. it can be idiopathic or inherited from a parent, or caused by another disease. we report a rare case of human immunodeficiency virus (hiv) infection in a 3-year-old boy who referred with acute abdominal pain, and was lat...

cd27 is a biomarker associated with both t-cells and b-cells activation .plasma soluble cd27 (scd27) was identified as  a marker of disease outcome in human immunodeficiency virus (hiv) infection .testing of plasma scd27 represents a good tool to monitor the change of immune activation during hiv infection.we sought to analyses role of hepatitis c virus (hcv) and also gb virus type c (gbv-c) co...

Despite great efforts to develop a vaccine against human immunodeficiency virus (HIV), which causes AIDS if untreated, no approved HIV is available date. A promising class of vaccines are virus-like particles (VLPs), were shown be very effective for the prevention other diseases. In this study, production HI-VLPs using different 293F cell lines, followed by three-step purification HI-VLPs, was ...

In an in vitro assay employing reconstituted nuclei, importin 7 (IPO7) has been implicated in nuclear translocation of human immunodeficiency virus type 1 (HIV-1) cDNA. Using RNA interference technology, we inhibited expression of IPO7 by 80 to 95% in primary macrophages and in HeLa cells and monitored their ability to support HIV-1 and simian immunodeficiency virus (SIV) cDNA synthesis, nuclea...

Vaginal rings releasing antiretrovirals - either alone or in combination with contraceptive progestins are being developed for contraception and prevention of human immunodeficiency virus (HIV) transmission via vagina. However, hormonal contraceptives associated numerous side effects contraindications, many women interested using hormone-free contraceptives. The aim this project is to develop m...