background: antifertility effect of naturally occuring antisperm antibody (asa) in infertile couples and studies on experimental immunization of various animals with sperm antigens represents asa as immunocontraceptive target. despite extensive research on the effects of different factors on sperm immunogenecity and asa production variable result have been reported. objective: to study whole sp...

introduction the extended program of immunization (epi) in iran is started in 1984, and it played an important and effective role in controlling many infectious diseases in community. the objective of this study was to determine the time trends of vaccination coverage by the type of vaccine among children, in the age group of 0-24 months, in iran from the beginning of epi (1984) to 2013. materi...

A challenge facing immunization registries is developing measures of childhood immunization coverage that contain more information for setting policy than present vaccine series up-to-date (UTD) rates. This study combined milestone analysis with provider encounter data to determine when children either do not receive indicated immunizations during medical encounters or fail to visit providers. ...

Streptococcus pneumoniae is an important cause of morbitity and mortality worldwide. Capsule-specific IgG1 and IgG2 Abs are induced upon vaccination with polysaccharide-based vaccines that mediate host protection. We compared the protective capacity of human recombinant serogroup 6-specific IgG1 and IgG2 Abs in mice deficient for either leukocyte FcR or complement factors. Human IgG1 was found ...

Live-vector human immunodeficiency virus (HIV) vaccines are an integral part of a number of HIV vaccine regimens currently under evaluation that have yielded promising results in pre-clinical testing. In this report, a non-pathogenic protozoan parasitic vector, Leishmania tarentolae, which shares common target cells with HIV-1, was used to express full-length HIV-1 Gag protein. Immunization of ...

Chemokines play a profound role in leukocyte trafficking and the development of adaptive immune responses. Perhaps due to their importance in host defense, viruses have adopted many of the hallmarks displayed by chemokines. In particular, viral MIP-II (vMIP-II) is a human chemokine homologue that is encoded by human herpes virus 8. vMIP-II is angiogenic, selectively chemotactic for Th2 lymphocy...

The hypothesis that atherosclerotic processes are mostly caused by immune (autoimmune) mechanisms has recently been gaining attraction. At the same time, autoimmune of atherogenesis not become generally accepted and requires additional evidence. Previously, we were able to induce changes in aortic wall similar those observed early stages human atherosclerosis, also produce visceral obesity norm...

This study aims to analyze the legal consequences arising from occurrence of Post Immunization Adverse Events (KIPI) in implementation complete basic immunization Banten Province. type research uses a normative juridical approach. Based on results study, it is known that AEFI immunization, both those who practice outside their authority and if an error occurs due negligence can be subject "disc...

The development of a safe and effective vaccine against SARS-CoV-2, the causative agent pandemic coronavirus disease-2019 (COVID-19), is global priority. Here, we aim to develop novel SARS-CoV-2 vaccines based on derivative less commonly used rare adenovirus serotype AdC68 vector. Three candidates were constructed expressing either full-length spike (AdC68-19S) or receptor-binding domain (RBD) ...