Human herpesvirus 8 (HHV-8)/Kaposi sarcoma-associated herpesvirus (KSHV) is linked to a number of malignancies thought to be driven by cytokines, including interleukin-6 (IL-6). Rta, a transcriptional activator encoded by HHV-8/KSHV, activates the viral lytic cycle leading to the expression of several viral genes implicated in viral pathogenesis. However, the effect of HHV-8/KSHV Rta on cellula...

Autoinoculation and dissemination (or Kaposi's varicelliform eruption or eczema herpeticum) of herpetic lesions are two forms of viral spread, and it is essential to differentiate between the two. Presented are typical examples of the two forms of viral spread.

BacMam viruses are modified baculoviruses that contain mammalian expression cassettes for viral gene delivery and transient expression in mammalian cells. They are easily, inexpensively, and rapidly generated and provide a versatile solution for G protein-coupled receptor (GPCR) cell-based assay development. Using BacMam technology, target gene expression levels are easily controlled and simult...

PATRICK S. MOORE,* SHOU-JIANG GAO, GERALDINA DOMINGUEZ, ETHEL CESARMAN, OCTAVIAN LUNGU, DANIEL M. KNOWLES, RICHARD GARBER, PHILIP E. PELLETT, DUNCAN J. MCGEOCH, AND YUAN CHANG Division of Epidemiology, Department of Microbiology, and Department of Pathology, Columbia University, New York, New York 10032; Centers for Disease Control and Prevention, Atlanta, Georgia 30333; Department of Pathology...

Article history: Received 5 May 2017 Accepted 5 May 2017 Available online 5 May 2017 in providing earlier diagnoses. However, the sensitivity of these assays may limit the effectiveness of these methods and thereby underrepresent the prevalence of infections such as KSHV and EBV in the human population. Currently, the most common method is the detection of antibodies produced in response to vir...