Herpesviruses are the second leading cause of human viral diseases. Herpes SimplexVirus types 1 and 2 andVaricella-zoster virus produce neurotropic infections such as cutaneous and genital herpes, chickenpox, and shingles. Infections of a lymphotropic nature are caused by cytomegalovirus, HSV-6, HSV-7, and Epstein-Barr virus producing lymphoma, carcinoma, and congenital abnormalities. Yet anoth...

Abstract Background and Aims: To identify and isolation of viruses a susceptible cell is need which can be primary or line. The use of primary cells is laborious, time consuming and expensive, while the use of cell lines is much easier and faster. IRKHBK cell line was originated from primary cells of bovine kidney by continuous passage. The aim of this study was to introduce the IRKHBK cell ...

Herpes simplex virus (HSV) and varicella-zoster virus (VZV) are both human alpha-herpes viruses. They are capable of establishing latent infections in neural tissues and to reactive from these sites, determining the clinical features of the disease (primary infection versus recurrences). Infections with these viruses are common; an increased number of elderly and immunocompromised individuals w...

SUMMARY Herpes Zoster Cephalicus or Ramsey-Hunt syndrome is second only to Bells palsy as the most common cause of acute facial paralysis. The varicclla zoster virus is thought to be responsible for this syndrome; Involvement or the racial and auditory nerve. In this article, a patient who was admitted with vesticular eruption of the external car with facial paralysis, and auditory symptoms i...

Herpes simplex virus is a common virus that causes a variety of clinical presentations ranging from mild to life-threatening. Orolabial and genital herpes are common disorders that can often be managed in an outpatient setting; however, some patients do present to the emergency department with those conditions, and emergency clinicians should be aware of possible complications in the pediatric ...

Human cytomegalovirus (CMV) is increasingly recognized as an important human pathogen (43). This virus produces a series of clinical pictures varying from classic "Scytomegalic inclusion disease" to intrauterine death, prematurity, congential defects, infectious mononucleosis, postperfusion syndrome, and interstitial pneumonia in patients who have undergone organ transplantation (29, 43). It is...

Human cytotoxic T-cell (CTL) clones that lyse autologous cells infected with herpes simplex virus (HSV) type 1 or 2 were generated by stimulating lymphocytes with a recombinant vaccinia virus (recombinant vaccinia-gD-1 virus) that expresses HSV type 1 glycoprotein D (gD-1). Furthermore, CTL clones generated with HSV type 1 or with cloned gD-1 lysed autologous cells infected with the recombinant...

background: epstein-barr virus (ebv) has a great co relationship with human malignancies such as gastric carcinoma. synonymous codon investigations in viruses could help designing vaccine, to generate immunity. codon adaptation index (cai) has measured translation elongation rate, among the highly expressed genes. the aim of this study was: usage of “cai” to measure translation efficiency to kn...

Mutation of the p53 tumor suppressor gene is a recurring event in a variety of human cancers. Wild-type p53 may regulate cell proliferation and has recently been shown to repress transcription from several cellular promoters. We studied the effects of wild-type and mutant human p53 on the human proliferating-cell nuclear antigen promoter and on several viral promoters including the simian virus...