Xanthine oxidoreductase has been demonstrated in the heart of various species. However, its presence in human heart is still debated. In the literature, high to undetectable levels have been reported. We studied the arterial-venous urate difference across the heart of patients undergoing both routine cardiac catheterization and percutaneous transluminal coronary angioplasty. Urate is the end pr...

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bifid cardiac apex is a rare anomaly of human hearts. we report of the case of a 34-year-old man with a previous history of ventricular septal defect (vsd) and subvalvular pulmonary stenosis. he had undergone pulmonary commissurotomy and vsd closure 22 years before he was referred to our center for evaluation of progressive dyspnea. transthoracic echocardiography revealed atrial septal defect (...

Pathways producing and converting adenosine have hardly been investigated in human heart, contrasting work in other species. We compared the kinetics of enzymes associated with purine degradation and salvage in human and rat heart cytoplasm assaying for adenosine deaminase, nucleoside phosphorylase, xanthine oxidoreductase, AMP deaminase, AMP- and IMP-specific 5'-nucleotidases, adenosine kinase...

The development of a four-dimensional solid modeling system is described. The applied technique provides three-dimensional visualization and animation of the human heart during its activated phase (the cardiac cycle). The modeling procedure is based on medical data-images generated by a magnetic resonance (MR) scanner. The visualization of the moving heart is based on a new approach for modelin...

BACKGROUND In animal models, increased signaling through the calcineurin pathway has been shown to be sufficient for the development of cardiac hypertrophy. Calcineurin activity has been reported to be elevated in the myocardium of patients with congestive heart failure. In contrast, few data are available about calcineurin activity in patients with pressure overload or cardiomyopathic hypertro...

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We have cloned and sequenced cDNAs for three isoforms of the L-type voltage-dependent calcium channel subunit isolated from a normal human heart cDNA library. One of these subunits, designated JPa. hybridized with a 3.4-kb message, and the other two, designated Pb and pBc, hybridized with a message of approximately 1.9 kb. The presence of both of these latter two messages in human heart was con...

AIMS Angiotensin-converting enzyme (ACE), which metabolizes many peptides and plays a key role in blood pressure regulation and vascular remodeling, is expressed as a type-1 membrane glycoprotein on the surface of different cells, including endothelial cells of the heart. We hypothesized that the local conformation and, therefore, the properties of heart ACE could differ from lung ACE due to di...

b 3 -adrenoceptors are involved in metabolism, gut relaxation, and vascular vasodilation. However, their existence and role in the human heart have not been documented. We investigated the effects of several b -adrenoceptor agonists and antagonists on the mechanical properties of ventricular endomyocardial biopsies. In the presence of nadolol, a b 1 and b 2 -adrenoceptor antagonist, isoprenalin...