نتایج جستجو برای: human epidermal growth factor receptor 2

تعداد نتایج: 5017407  

Journal: :Journal of exploratory research in pharmacology 2022

Background and objectivesThe overexpression mutation of EGFRs are associated with various types human cancers. Epidermal growth factor receptor variant III (EGFRvIII) is one the most notable EGFR mutations, exclusively present in cancer cells, making it a potential therapeutic target. The study aims to determine whether recombinant immunotoxin 86 (rIT86) can effectively kill EGFRvIII-expressing...

2015
William J Howat Fiona M Blows Elena Provenzano Mark N Brook Lorna Morris Patrycja Gazinska Nicola Johnson Leigh‐Anne McDuffus Jodi Miller Elinor J Sawyer Sarah Pinder Carolien H M van Deurzen Louise Jones Reijo Sironen Daniel Visscher Carlos Caldas Frances Daley Penny Coulson Annegien Broeks Joyce Sanders Jelle Wesseling Heli Nevanlinna Rainer Fagerholm Carl Blomqvist Päivi Heikkilä H Raza Ali Sarah‐Jane Dawson Jonine Figueroa Jolanta Lissowska Louise Brinton Arto Mannermaa Vesa Kataja Veli‐Matti Kosma Angela Cox Ian W Brock Simon S Cross Malcolm W Reed Fergus J Couch Janet E Olson Peter Devillee Wilma E Mesker Caroline M Seyaneve Antoinette Hollestelle Javier Benitez Jose Ignacio Arias Perez Primitiva Menéndez Manjeet K Bolla Douglas F Easton Marjanka K Schmidt Paul D Pharoah Mark E Sherman Montserrat García‐Closas

Breast cancer risk factors and clinical outcomes vary by tumour marker expression. However, individual studies often lack the power required to assess these relationships, and large-scale analyses are limited by the need for high throughput, standardized scoring methods. To address these limitations, we assessed whether automated image analysis of immunohistochemically stained tissue microarray...

2017
Hiromi Watanabe Eiki Ichihara Hirohisa Kano Kiichiro Ninomiya Mitsune Tanimoto Katsuyuki Kiura

We herein report a case of congestive heart failure which developed during osimertinib treatment. A 78-year-old woman presented with mild exertional dyspnea three weeks after starting osimertinib for the treatment of epidermal growth factor receptor (EGFR) T790M-positive non-small cell lung cancer. She was diagnosed with congestive heart failure caused by the osimertinib. In contrast to trastuz...

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