Androgen receptor (AR) is a ligand-inducible transcription factor, and a member of the steroid-thyroid-retinoid receptor superfamily, that mediates the biological effects of androgens in a wide range of physiological and pathological processes. AR expression was identified in vascular cells nearly 20 years ago, and recent research has shown that AR mediates a variety of actions of androgens in ...

BACKGROUND AND AIMS Although Breast carcinoma had many targeted biomarkers for its treatment, however, it is a heterogeneous disease with different outcomes and need new markers especially for the triple negative group when estrogen receptor, progesterone receptors and Her2/neu are negative. Androgen receptor is a new target with unclear role. The aim of this study was to examine the prevalence...

This review presents the androgen receptor gene and its clinical importance in gynecology, oncology and infertility. A computerized literature search through Medline and PubMED was performed, applying the word " androgen receptor " cited between the years 1990 and 2009. The androgen receptor mediates androgen action, determining male sexual phenotypes and spermatogenesis. Constitutional mutatio...

During the last 5 years, research on Human Activity Recognition (HAR) has reported on systems showing good overall recognition performance. As a consequence, HAR has been considered as a potential technology for ehealth systems. Here, we propose a machine learning based HAR classifier. We also provide a full experimental description that contains the HAR wearable devices setup and a public doma...

Human Activity Recognition (HAR) is aimed at identifying current subject task performed by a person as a result of analyzing data from wearable sensors. HAR is a very challenging task that has been applied in different areas such as rehabilitation, localization, etc. During the past ten years, plenty of models, number of sensors and sensor placements, and feature transformations have been repor...

Background: Neuroblastoma is the most common extracranial tumors in children. At present about the true etiology of neuroblastoma is unclear and many studies have tried to find effective treatments for these primary malignant tumors. Although it has been illustrated that androgen receptor (AR) was expressed in neuroblastoma cells in some former reports, the biological role of androgen receptor ...

Many Human Activity Recognition (HAR) systems are able to detect sequential executed Activity of Daily Living (ADL). However, a person is capable of doing two things in parallel or pausing one ADL and finishing it later. Thus, a HAR system must be capable of remembering and deciding which ADL is completed and which might be continued after the current ADL. We address this case by combining a st...

Animal studies showed that male gastric tissues respond more rapidly to Helicobacter pylori (H.pylori) infection but the possible mechanisms remained unclear. There is no data about gender specific activity of Androgen receptor (AR) as an independent unfavorable prognostic factor in gastric cancer and its interactions with H.pylori and angiogenesis in both genders. To compare the pathogenesis o...

Androgen receptor signaling plays a critical role in prostate cancer pathogenesis. Yet, the regulation of androgen receptor signaling remains elusive. Even with stringent androgen deprivation therapy, androgen receptor signaling persists. Here, our data suggest that there is a complex interaction between the expression of the tumor suppressor miRNA, miR-31, and androgen receptor signaling. We e...

The androgen receptor is a member of the family of nuclear receptors. In its activated form as an androgen receptor ligand complex (the ligand can either be testosterone or 5a-dihydrotestosterone), the androgen receptor is able to regulate a specific expression of target genes. The androgen receptor is expressed at high levels in male reproductive tissues. Mutations in the androgen receptor gen...