background: pectic acid extracted from plants increases the secretion of prolactin (prl) when injected intravenously into ewes or fed to rats. fragments of ewe hypophysis and lactating rabbit mammary gland incubated in vitro in the presence of pectic acid secreted more prl and caseins compared to the controls. however, it is not known whether pectic acid directly stimulates prl secretion in pit...

stem cell research has obtained much prominence in recent years for its therapeutic potential in dealing with serious diseases, many of which are essentially incurable by routine therapies. mesenchymal stem cells with pluripotency and immunomodulatory properties are suitable candidates for tissue engineering and regenerative medicine. today, nanofibrous scaffolds are widely used in tissue engin...

introduction: d-galactose (d-gal) is well known as an appropriate agent to induced aging effects in the in vivo and in vitro models. in the present study, we selected crocin, the main constituent of crocus sativus l. (saffron), against d-gal cytotoxicity in human neuroblastoma sh-sy5y cells. materials and methods:  cells were pretreated with crocin (25-500 µm) for 24 h and then exposed to d-gal...

objective(s): to investigate the effect of cinnamaldehyde and eugenol on the telomere-dependent senescence of stem cells. in addition, to search the probable targets of mentioned phytochemicals between human telomere interacting proteins (tips) using in silico studies. materials and methods: human adipose derived stem cells (hascs) were studied under treatments with 2.5 µm/ml cinnamaldehyde, 0....

dead yeast cells are an abundant residue of the brazilian ethanol industry and the industries still don’t have a proper or desirable destiny for all these cells, which means tons of vitamins and proteins that have not a major end. in the other hand, heavy metal residues are a problem, especially for leather industry, where brazil is also a great producer. in this work, dead yeast cells were us...

it is well known that several plant extracts have a lactogenic effect. this response may be inducedthrough the stimulation of prolactin release from lactotrope cells. a partial purification of the activecompound indicated that it is rich in pectin and β-glucan. these materials stimulate secretion of prolactinfrom hypophyseal fragments. in the present study, the effect of β-glucan on the secreti...

embryonic stem cells (escs) are originally derived from the icm of blastocysts and are characterized by their ability to self-renew and their pluripotencies. only a few reports have been published on esc isolations and line establishment in animals, even fewer in horses. however, it is still important to isolate equine escs for animal biotechnology and therapeutic applications. in the present s...

objective: endometriosis is a common disease in which the endometrial stroma and glands grow abnormally outside the uterine cavity. the establishment of animal models can be effective for determining the etiology of endometriosis. in this study we compare two endometriosis models using endometrial fragments and isolated cultured endometrial cells. methods: we obtained endometrial tissues that ...

the human placenta has long been the subject of scientific interest due to the important roles which it performs during pregnancy in sustaining the fetus and maintaining fetomaternal tolerance. more recently, however, researchers have begun to investigate the possibility that the placenta’s utility may extend beyond fetal development to act as a source of cells with clinically relevant properti...

unilateral orchidectomy (uo) is required when further breeding potential is important. it is sometimes necessary to remove a single testis in a matured stallion for therapeutic reasons. in this study, twelve donkeys were used to evaluate three techniques of unilateral castration, histological and morphological changes on the remaining testis. results of the study showed that each of the surgica...