A convenient method for the separation of molecular species of complex lipids such as sphingomyelin and ceramide by argentation high performance liquid chromatography (HPLC) is described for the first time. Molecular species separation of these complex lipids was achieved for quantitative analysis and preparative work by the combined use of argentation and reversed-phase HPLC.-Smith, M., P. Mon...

niosomes are non-ionic surfactant vesicles that have potential applications in the delivery of hydrophilic and hydrophobic drugs. the topical form of n-acetyl glucosamine (nag) recently has been considered in the treatment of hyperpigmentation disorders due to its inhibitory effect on thyrosinase enzymes in melanocytes. to improve nag penetration into the skin we formulated the drug in niosomes...

background nowadays, adsorption techniques are widely used to remove certain classes of pollutants from water. objectives the aim of this study was to remove ametryn from water solutions by natural zeolite nanoparticles from the semnan region of iran. materials and methods for this purpose zeolite nanoparticles were synthesized from natural zeolite using planetary ball-mill. the zeolite nanopar...

background & aims of the study: antibiotics utilize with the aim of improving human, animal and plant health; also, for treating infections caused by pathogenic bacteria. when these compounds introduce into ecosystems, could affect the microbial community and jeopardize human health. therefore, the aim of present study is to determination of the presence of six common utilized antibiotics (amox...

cefquinome sulfate (cs) is a fourth-generation cephalosporin, which has been developed solely for veterinary use. it shows potent antibacterial activity against a broad spectrum of bacterial species. however, cefquinome is susceptible to hydrolysis, which limiting its clinical employment efficacies to some extent. so, in this study, to increase cefquinome sulfate biological half-life, a novel c...

nifedipine (nif) a 1, 4-dihydropyridine calcium channel antagonist, undergoes photodegradation to nitroso analogues of dehydronifedipine (ndnif) when exposed to sunlight. photodegradation products of nif have no clinical activity, so different formulations of nif must remain unchanged. if nif preparations become unstable in exposure to light, they could cause therapeutic failure. the present st...

the accurate prediction of protein stability is one of the most challenging goals in protein formulation and delivery. in this study, a gradient rp-hplc method is described for the separation of human growth hormone (hgh) variants as deamidated and oxidized forms. the methodology employed a polymeric poly (styrene-co-divinylbenzene) column and a 1ml/min flow rate of a linear gradient of 0.1% v/...