Topicality. Сlemastine fumarate (tavegil)-1-methyl-2 [2-α-methyl-p-chlorobenzhydryloxy)-ethyl]-pyrrolidine is the first generation H1-histamine receptor blocker. selectively inhibits histamine H1 receptors and reduces capillary permeability. The drug has a pronounced anti-allergic antipruritic effect. Clemastine prevents development of vasodilation smooth muscle contraction induced by histamine...