Using the statistical analysis of genetic variation, we have developed a high-resolution genetic map of recombination hotspots and recombination rate variation across the human genome. This map, which has a resolution several orders of magnitude greater than previous studies, identifies over 25,000 recombination hotspots and gives new insights into the distribution and determination of recombin...

With the development of industrialization rapidly, vehicles have become an important part of people’s life. However, transportation system is becoming more and more complicated. The core problem of the complicated transportation system is how to avoid hotspots. In this paper, we present a graph model based on a multi-dimension weighted graph for path planning with avoiding hotspots. Firstly, we...

Mammalian meiotic recombination, which preferentially occurs at specialized sites called hotspots, ensures the orderly segregation of meiotic chromosomes and creates genetic variation among offspring. A locus on mouse chromosome 17, which controls activation of recombination at multiple distant hotspots, has been mapped within a 181-kilobase interval, three of whose genes can be eliminated as c...

Although present in both humans and chimpanzees, recombination hotspots, at which meiotic crossover events cluster, differ markedly in their genomic location between the species. We report that a 13-base pair sequence motif previously associated with the activity of 40% of human hotspots does not function in chimpanzees and is being removed by self-destructive drive in the human lineage. Multip...

Hotspots and coldspots of concentration and biodegradation of polycyclic aromatic hydrocarbons (PAHs) marginally overlapped at the 0.5-100 m scale in a creosote contaminated soil in southern Sweden, suggesting that concentration and biodegradation had little spatial co-variation. Biodegradation was substantial and its spatial variability considerable and highly irregular, but it had no spatial ...

Mobile hotspots, i.e. Internet access services in moving networks (e.g. vehicular area networks (VAN) and personal area networks (PAN)) bring about new challenging issues. Even if the network mobility (NEMO) basic support protocol has been standardized as a mobility solution by the Internet Engineering Task Force (IETF), to the best of our knowledge, no studies have been conducted in the area o...

LOAD BALANCING HOTSPOTS IN SENSOR STORAGE SYSTEMS

Click-based graphical passwords, like other user-selected passwords, suffer from predictability problems. With click-based graphical passwords, user click-points form hotspots, areas of the image that are more likely to be selected, which e-criminals can predict and use to launch dictionary attacks. Our system, Persuasive Cued Click-Points, helps users select more random click-points and reduce...

In the yeast Saccharomyces cerevisiae, meiotic recombination is initiated by double-strand DNA breaks (DSBs). Meiotic DSBs occur at relatively high frequencies in some genomic regions (hotspots) and relatively low frequencies in others (coldspots). We used DNA microarrays to estimate variation in the level of nearby meiotic DSBs for all 6,200 yeast genes. Hotspots were nonrandomly associated wi...

In many mammals, including humans and mice, the zinc finger histone methyltransferase PRDM9 performs the first step in meiotic recombination by specifying the locations of hotspots, the sites of genetic recombination. PRDM9 binds to DNA at hotspots through its zinc finger domain and activates recombination by trimethylating histone H3K4 on adjacent nucleosomes through its PR/SET domain. Recentl...