Understanding the molecular basis of plant resistance to fungal diseases will contribute to reducing world-wide crop losses. One model organism for studying disease resistance is Arabidopsis thaliana, a small member of the mustard family for which complete genomic sequence information was publicly released in 2000. Erysiphe cichoracearum, the causative agent for powdery mildew disease in a wide...

Gut microbiota and their metabolites have been linked to a series of chronic diseases such as obesity and other metabolic dysfunctions. Obesity is an increasingly serious international health issue that may lead to a risk of insulin resistance and other metabolic diseases. The relationship between gut microbiota and the host is both interdependent and relatively independent. In this review, the...

Recent theoretical work has shown that long-lived hosts are expected to evolve higher equilibrium levels of disease resistance than shorter-lived hosts, but questions of how longevity affects the rate of resistance evolution and the maintenance of polymorphism remain unanswered. Conventional wisdom suggests that adaptive evolution should occur more slowly in long-lived organisms than in short-l...

In 2020, the WHO established road map for neglected tropical diseases 2021–2030, which aims to control and eradicate 20 diseases, including leishmaniosis Chagas disease. addition, since 2015, has been developing a Global Action Plan on Antimicrobial Resistance. this context, achievement of innovative strategies as an alternative replace conventional therapies is first-order socio-sanitary prior...

Debates on the relative merits of resistance (the ability of the host to control the parasite lifecycle) and tolerance (the net impact of infection on host performance) are often lively and unhindered by data or evidence. Resistance generally shows continuous, heritable variation but data are sparser for tolerance, the utility of which will depend upon the disease prevalence. Prevalence is a fu...

Resistance to diseases caused by turnip mosaic virus (TuMV) in crop species of the family Brassicaceae has been studied extensively, especially members genus Brassica. The variation response observed on resistant and susceptible plants inoculated with different isolates TuMV is due a combination plant resistome genome. Here, we review breadth this variation, both at level sequences, one eye tow...

multipotent mesenchymal stromal cells or mesenchymal stem cells (mscs) are mainly isolated from bone marrow or fat tissue. because of their potential of multilineage differentiation towards bone, cartilage and fat tissue, they were initially evaluated to develop innovative strategies for tissue engineering applications. more recently, they have gained interest based on their immunomodulatory pr...