background: elevated level of plasma homocysteine has been related to various diseases. patients with hyperhomocysteinemia can develop hepatic steatosis and fibrosis. we hypothesized that oxidative stress induced by homocysteine might play an important role in pathogenesis of liver injury. also, the cellular response designed to combat oxidative stress is primarily controlled by the transcripti...

Background: Elevated level of plasma homocysteine has been related to various diseases. Patients with hyperhomocysteinemia can develop hepatic steatosis and fibrosis. We hypothesized that oxidative stress induced by homocysteine might play an important role in pathogenesis of liver injury. Also, the cellular response designed to combat oxidative stress is primarily controlled by the transcripti...

recent studies have documented the importance of lipids and lipoproteins as determinants of serum total homocysteine concentrations in persons with myocardial infarction, and in healthy subjects. associations between various biological systems and total homocysteine have also been reported. however, some of these associations are poorly understood. the purpose of our study was to measure serum ...

Background and Objectives: Type 2 diabetes is the most prevalent form of diabetes mellitus and is associated with a variety of complications. Homocysteine is an important independent risk factor for atherosclerotic diseases in both diabetic and non diabetic subjects. The association between these two is still unclear. The aim of this study was to assess the serum homocysteine levels in uncompli...

OBJECTIVE: Level of serum homocysteine is remarkably common among patients with moderate to sever renal failure. We assessed whether serum homocysteine concentrations were correlated with proteinuria in overt diabetic nephropathy. MATERIALS AND METHODS: A cross-sectional study was carried out on 45 patients (29 males, 16 females) with overt proteinuria. All subjects had type 2 diabetes. Data i...

Introduction: Homocysteine is an aminoacid yielded from methionin to cysteine metabolism. Normal plasma concentration of homocysteine in human is between 5-15 mol/l and an increase more than 5 mol/l can increase the risk of cardiovascular diseases, atherosclerosis and thrombosis. On the other hand in dialysis patients due to some reasons such as uremia, genetic factors, dialysis related factors...

introduction: elevated plasma total homocysteine is an independent risk factor for cardiovascular disease and a sensitive marker of vitamin b12 and folate insufficiency. folate and vitamin b12 have a protective effect on cardiovascular disease. this effect may be partly explained by mechanisms independent of homocysteine. this survey is the first population based study to evaluate the plasma to...

UNLABELLED The accessory growth regulator (Agr)-like quorum sensing (QS) system of Clostridium perfringens controls the production of many toxins, including beta toxin (CPB). We previously showed (J. E. Vidal, M. Ma, J. Saputo, J. Garcia, F. A. Uzal, and B. A. McClane, Mol Microbiol 83:179-194, 2012, http://dx.doi.org/10.1111/j.1365-2958.2011.07925.x) that an 8-amino-acid, AgrD-derived peptide ...