نتایج جستجو برای: hmg و r

تعداد نتایج: 1198316  

Journal: :Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1995
S Seronie-Vivien A Pradines B Couderc C Clamagirand D Berg G Soula G Favre

3-Hydroxy-3-methylglutaryl CoA reductase (HMG-CoA reductase) plays a rate-limiting role in isoprenoid biosynthesis and is associated with cell proliferation and transformation. Although an elevated level of HMG-CoA reductase activity is consistently detected in cancer cell lines and tumors, the question remains whether HMG-CoA reductase activity may have a causative role in cell transformation....

2008
Iman M. Ahmad Maher Y. Abdalla Noor H. Mustafa Esam Y. Qnais Fuad A. Abdulla

صخلملا This study was designed to evaluate the cytotoxic effect ةتبن قارولأ يئاملا صلختسملا ةيمس ىدم ميقتل ةساردلا هذه تممص ايلاخ ضر MDA-MB231 و FaDu ةدملل ةيناطرسلا ايلاخلا ةجلا يف تابارطضاب صلختسملا اذهب لختسم ص ملا ةتبن قارولأ يئا © 2009 Jordan Journal of Biological Sciences. All rights reserved

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1984
Z H Beg J A Stonik H B Brewer

It has been previously demonstrated that the enzymic activity of rat liver 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase; EC 1.1.1.34) is modulated in vitro and in vivo by a bicyclic cascade system involving reversible phosphorylation of HMG-CoA reductase and reductase kinase. In the present study, administration of mevalonolactone to rats caused a rapid inhibition of HMG-C...

2013
Jinane Ait Benkhali Evelyne Coppin Sylvain Brun Leonardo Peraza-Reyes Tom Martin Christina Dixelius Noureddine Lazar Herman van Tilbeurgh Robert Debuchy

High-mobility group (HMG) B proteins are eukaryotic DNA-binding proteins characterized by the HMG-box functional motif. These transcription factors play a pivotal role in global genomic functions and in the control of genes involved in specific developmental or metabolic pathways. The filamentous ascomycete Podospora anserina contains 12 HMG-box genes. Of these, four have been previously charac...

Journal: :Biochemical Society transactions 1995
F G Hegardt

The enzyme 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase catalyses the condensation of acetoacetyl-CoA and acetyl-CoA to form HMGCoA plus free CoA. The activity of HMG-CoA synthase is located in two different compartments: the cytosol and the mitochondria. The HMG-CoA produced by cytosolic HMG-CoA synthase is transformed into mevalonate by the action of HMG-CoA reductase, thus starting the ...

Journal: :journal of sciences islamic republic of iran 0

in this study, the interaction of the anthracycline antibiotic doxorubicin with dna-hmg 1 complex was investigated employing uv/vis spectroscopy, thermal denaturation and dna cellulose chromatography techniques. the results indicated that the binding of doxorubicin to the protein reduces its tm in a dose dependent manner. although doxorubicin protects free dna against thermal denaturation in th...

Journal: :International Journal of Health Sciences (IJHS) 2022

Background: Polycystic ovarian syndrome (PCOS) is a multifaceted that affects multipleorgan systems with significant metabolic and reproductive manifestations. Treatment must be individualized on the basis of patient’s presentation, desire for pregnancy. Objective: To study role letrozole (LE) low dose human menopausal gonadotrophen (HMG) ovulation induction in polycystic patients. Material &am...

Journal: : 2023

Polycystic ovary syndrome is a common cause of an ovulatory infertility. Drugs like Aromatase inhibitors, Human menopausal gonadotropin, used for ovulation induction. The aim this study was carried out to compare the therapeutic effects gonadotropin hormone versus oral ovarian stimulating agents. A prospective randomized controlled clinical trial in Salahdeen general hospital Tikrit from 1st Fe...

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