Background: Saving time means saving neurons in stroke care process. Managerial and organizational solutions that lean the processes should be considered in order to overcome the effects of stroke, which is the second worldwide cause of death. The purpose of the paper is to understand how Health Lean Management (HLM) can be adopted to achieve a more efficient stroke care process. In this peculi...

A higher throughput method of screening for the inhibition of recombinant CYP2D6 using a microtiter plate (MTP) assay was evaluated using 62 new chemical entities and compared to data from the dextromethorphan O-demethylase assay in human liver microsomes (HLM). The IC50 values for the two assays closely matched for 53 compounds (85%). Six of the variant nine compounds had higher IC50 values wi...

Esculetin (6,7-dihydroxycoumarin, ET) and 4-methylesculetin (6,7-dihydroxy-4-methylcoumarin, 4-ME) are typical coumarin derivatives that are attracting considerable attention because of their wide spectrum of biologic activities, but their metabolism remains unknown. This study aimed to elucidate the in vitro UDP-glucuronosyltransferase (UGT) metabolism characteristics of ET and 4-ME. 7-O-monog...

As a direct-acting inhibitor of CYP2C19 in vitro, lansoprazole is more potent than omeprazole and other proton pump inhibitors (PPIs), but lansoprazole does not cause clinically significant inhibition of CYP2C19 whereas omeprazole does. To investigate this apparent paradox, we evaluated omeprazole, esomeprazole, R-omeprazole, lansoprazole, and pantoprazole for their ability to function as direc...

BACKGROUND Although numerous epidemiological studies on cholecystectomy have been conducted worldwide, only a few have considered the effect of socioeconomic inequalities on cholecystectomy outcomes. Specifically, few studies have focused on the low-income population (LIP). METHODS A nationwide prospective study based on the Taiwan National Health Insurance dataset was conducted during 2003-2...

The purpose of this study is to discuss the impact social responsibility on company's value. Taking Xiaomi Company as a case, research objects are decision-making level, management level and grass-roots employees by questionnaire survey. sampling method purposive sampling. 125 groups samples (decision-making level) 623 (grass-roots employees) sampled. Hierarchical model (HLM) hierarchical regre...

Objective The purpose of this study was to compare the effects of Glycyrrhiza glabra (Licorice), Cyclooxygenase-2 Inhibitor (Celecoxib®) and gonadotropin releasing hormone analog (Diphereline®) to a control group on endometrial implants in rats. MaterialsAndMethods Endometriosis was induced in rats by auto transplantation and after confirmation, the rats were divided into 4 groups that were tre...