نتایج جستجو برای: hiv vaccine
تعداد نتایج: 309384 فیلتر نتایج به سال:
Induction of HIV-specific T-cell responses by vaccines may facilitate efficient control of HIV. Plasmid DNA vaccines and recombinant fowlpoxvirus (rFPV) vaccines are promising HIV-1 vaccine candidates, although either vaccine alone may be insufficient to protect against HIV-1. A consecutive immunisation strategy involving priming with DNA and boosting with rFPV vaccines encoding multiple common...
background: development of an effective vaccine is highly needed in order to restrict the aids pandemic. dna vaccines initiate both arms of immunity without the potential of causing disease. hiv-1 p24 and gp41 (gag and env) proteins play important roles in viral pathogenesis and are effective candidates for immune induction and vaccine design. objective: in this study, new dna vaccine candidate...
Citation: Kim B-J, Kim B-R, Kook Y-H and Kim B-J (2018) Development of a Live Recombinant BCG Expressing Human Immunodeficiency Virus Type 1 (HIV-1) Gag Using a pMyong2 Vector System: Potential Use As a Novel HIV-1 Vaccine. Front. Immunol. 9:643. doi: 10.3389/fimmu.2018.00643 Development of a live recombinant Bcg expressing human immunodeficiency Virus Type 1 (hiV-1) gag Using a pMyong2 Vector ...
At least five distinct genetic subtypes (genotypes) of human immunodeficiency virus type 1 (HIV-1) have been identified by DNA sequencing. Current vaccine candidates are based on virus strains from North America and Europe that represent only one subtype. The extent to which distinct genotypes of HIV-1 correspond to antigenically distinguishable serotypes is largely unknown and may be criticall...
A t the end of 2005, about 40 million people worldwide were living with HIV/AIDS, most of them adults and 95 percent of them living in developing countries. Although vigorous prevention programs are under way in many countries, about 3 million people still died from AIDS in 2005 and more than 13,000 people became infected with HIV every day [1]. Hence there is an urgent need for stronger and mo...
BACKGROUND The development of an HIV/AIDS vaccine has proven to be elusive. Because human vaccine trials have not yet demonstrated efficacy, new vaccine strategies are needed for the HIV vaccine pipeline. We have been developing a new HIV vaccine platform using a live enterovirus, coxsackievirus B4 (CVB4) vector. Enteroviruses are ideal candidates for development as a vaccine vector for oral de...
Objective 1: Define the safety and efficacy of the multiclade DNA prime/rAd5 boost VRC candidate HIV-1 vaccine. Objective 2: Define immunological correlates of vaccine-induced protection from HIV-1 acquisition and/or disease progression to advance development of an HIV-1 candidate Objective 1: Determine the structure of a trimeric HIV-1 Envelope spike and delineate how oligomerization influence...
Induction of high levels of broadly reactive cytotoxic T lymphocytes (CTL) remains a promising approach for an effective HIV-1 vaccine. We have developed a novel genetic-based vaccine strategy that encodes consensus overlapping peptide sets from all HIV-1 proteins scrambled together. This synthetic scrambled antigen vaccine (SAVINE) strategy has significant advantages, e.g. capacity to encode m...
BACKGROUND The Phase 2b double-blinded, randomized Phambili/HVTN 503 trial evaluated safety and efficacy of the MRK Ad5 gag/pol/nef subtype B HIV-1 preventive vaccine vs placebo in sexually active HIV-1 seronegative participants in South Africa. Enrollment and vaccinations stopped and participants were unblinded but continued follow-up when the Step study evaluating the same vaccine in the Amer...
Persistent B cell responses in mucosal tissues are crucial to control infection against sexually transmitted pathogens like human immunodeficiency virus 1 (HIV-1). The genital tract is a major site of infection by HIV. Sublingual (SL) immunization in mice was previously shown to generate HIV-specific B cell immunity that disseminates to the genital tract. We report here the immunogenicity in fe...
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