نتایج جستجو برای: hiv 1 dna vaccine

تعداد نتایج: 3346593  

Journal: :American Journal of Hematology 1996

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Journal: :Viral Immunology 2013

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Journal: :American Journal of Hematology 1996

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Journal: :BMJ 2002
Roy D Mugerwa Pontiano Kaleebu Peter Mugyenyi Edward Katongole-Mbidde David L Hom Rose Byaruhanga Robert A Salata Jerrold J Ellner

Trials of the HIV-1 vaccine have been conducted in Europe, North America, Brazil, China, and Thailand. The first trial of a candidate vaccine in Africa was recently completed in Uganda. It involved a randomised, placebo controlled trial of a vaccine in healthy volunteers at low risk of HIV infection. 3 The vaccine, called “ALVAC-HIV,” uses a live recombinant canarypox vector to express envelope...

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2014
Paul F. McKay Alethea V. Cope Jamie F. S. Mann Sarah Joseph Mariano Esteban Roger Tatoud Darrick Carter Steven G. Reed Jonathan Weber Robin J. Shattock

Using a unique vaccine antigen matched and single HIV Clade C approach we have assessed the immunogenicity of a DNA-poxvirus-protein strategy in mice and rabbits, administering MVA and protein immunizations either sequentially or simultaneously and in the presence of a novel TLR4 adjuvant, GLA-AF. Mice were vaccinated with combinations of HIV env/gag-pol-nef plasmid DNA followed by MVA-C (HIV e...

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Journal: :Annual Review of Medicine 2010

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Journal: :Vaccines 2016
Chongbo Zhao Zhujun Ao Xiaojian Yao

HIV-1 virus-like particles (VLPs) are promising vaccine candidates against HIV-1 infection. They are capable of preserving the native conformation of HIV-1 antigens and priming CD4+ and CD8+ T cell responses efficiently via cross presentation by both major histocompatibility complex (MHC) class I and II molecules. Progress has been achieved in the preclinical research of HIV-1 VLPs as prophylac...

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Journal: :The Journal of infectious diseases 2002
Mary A Marovich John R Mascola Michael A Eller Mark K Louder Pierre A Caudrelier Raphaelle El-Habib Silvia Ratto-Kim Josephine H Cox Jeffrey R Currier Bruce L Levine Carl H June Wendy B Bernstein Merlin L Robb Beatrice Schuler-Thurner Ralph M Steinman Deborah L Birx Sarah Schlesinger-Frankel

Preclinical data are reported that support a human immunodeficiency virus (HIV) vaccine strategy using recombinant canarypox-HIV vectors (ALVAC-HIV) to load human dendritic cells (DCs) with HIV antigens. Clinical-grade DCs were infected with good manufacturing practice-grade ALVAC-HIV vaccine constructs. ALVAC infection, HIV gene expression, and DC viability and function were monitored by use o...

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Journal: :Vaccine 2005
Robert De Rose Socheata Chea C Jane Dale Jeanette Reece Caroline S Fernandez Kim M Wilson Scott Thomson Ian A Ramshaw Barbara E H Coupar David B Boyle Mark T Sullivan Stephen J Kent

To induce broad T cell immunity to HIV-1, we evaluated the safety, immunogenicity and dose-response relationship of DNA and recombinant Fowlpoxvirus (rFPV) vaccines encoding five shared HIV subtype AE genes (Gag, Pol, Env, Tat, Rev) in pigtail macaques. The DNA (three doses of either 1 mg or 4.5 mg) and rFPV (a single boost of either 5 x 10(7) or 2 x 10(8) plaque forming units) vaccines were ad...

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Journal: :Cell 2014

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    • "; pgn_html+=pgn_li; } document.getElementById("pgn-ul").innerHTML=pgn_html var pgn_links = document.querySelectorAll('.mypgn'); pgn_links.forEach(function(pgn_link) { pgn_link.addEventListener('click', paginate) }) } function post_and_fetch(data,url) { showLoading() xhr = new XMLHttpRequest(); xhr.open('POST', url, true); xhr.setRequestHeader('Content-Type', 'application/json; charset=UTF-8'); xhr.onreadystatechange = function() { if (xhr.readyState === 4 && xhr.status === 200) { var resp = xhr.responseText; resp_json=JSON.parse(resp) resp_place = document.getElementById("search_result_div") resp_place.innerHTML = resp_json['results'] search_meta = resp_json['meta'] update_search_meta(search_meta) update_pagination() hideLoading() } }; xhr.send(JSON.stringify(data)); } function unfilter() { url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":"unfilter", "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } function deactivate_all_bars(){ var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(bar) { bar.dataset.active = false bar.style = "stroke:#71a3c5;" }) } year_chart.on("created", function() { var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(check) { check.addEventListener('click', checkIndex); }) }); function checkIndex(event) { var yrchart = document.querySelectorAll('.ct-bar'); var year_bar = event.target if (year_bar.dataset.active == "true") { unfilter_res = unfilter() year_bar.dataset.active = false year_bar.style = "stroke:#1d2b3699;" } else { deactivate_all_bars() year_bar.dataset.active = true year_bar.style = "stroke:#e56f6f;" filter_year = chart_data['labels'][Array.from(yrchart).indexOf(year_bar)] url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":filter_year, "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } } function showLoading() { document.getElementById("loading").style.display = "block"; setTimeout(hideLoading, 10000); // 10 seconds } function hideLoading() { document.getElementById("loading").style.display = "none"; } -->