Epigenome-wide association studies (EWAS) are designed to characterise population-level epigenetic differences across the genome and link them to disease. Most commonly, they assess DNA-methylation status at cytosine-guanine dinucleotide (CpG) sites, using platforms such as the Illumina 450k array that profile a subset of CpGs genome wide. An important challenge in the context of EWAS is determ...

Lung injuries are common among those who suffer an impact or trauma. The relative severity of injuries up to physical tearing of tissue have been documented in clinical studies. However, the specific details of energy required to cause visible damage to the lung parenchyma are lacking. Furthermore, the limitations of lung tissue under simple mechanical loading are also not well documented. This...

The properties of astroglial gap junction channels and the protein that constitutes the channels were characterized by immunocytochemical, molecular biological, and physiological techniques. Comparative immunocytochemical labeling utilizing different antibodies specific for liver connexin 32 and connexin 26 and antibodies to peptides corresponding to carboxy-terminal sequences of the heart gap ...

one glass bead of 3 mm diameter per 5 mnl of blood. If this is not practicable blood may be collected into heparin and then defibrinated in the same manner after the addition of excess thrombin to neutralize the heparin. Blood from patients on chronic dialysis often requires the addition of thrombin to facilitate defibrination because of the residual heparin and other circulating anticoagulants...

BACKGROUND AND OBJECTIVE Knowledge about optical parameters and the resultant light distribution in laser-treated tissue is important for predicting the effects of laser-induced thermotherapy of liver metastases (LITT). MATERIALS AND METHODS The absorption and scattering coefficients as well as the anisotropy factors and the optical penetration depths of human liver tissue and colorectal live...

Machine learning techniques for cancer prediction and biomarker discovery can hasten cancer detection and significantly improve prognosis. Recent "OMICS" studies which include a variety of cancer and normal tissue samples along with machine learning approaches have the potential to further accelerate such discovery. To demonstrate this potential, 2,175 gene expression samples from nine tissue t...

In this paper, we analyzed the segmentation of MRI brain image into different tissue types on brain image using Possibilistic fuzzy c-means (PFCM) clustering. Application of this method to MRI brain image gives the better segmentation result in compare with Fuzzy c-mean (FCM) and fuzzy possibilistic c-means (FPCM). The results are verified quantitatively using similarity metrics, false positive...

The following three articles (1, 3, 4) describe the demon stration of the three versions of the LAI1assay: hemocytom eten, test tube, and microtest. The initial purpose of this demonstration was to give the participants an opportunity to view how fellow investigators perform the different as says as well as to give the observers an opportunity to learn one of the three LAI assays from an expert...

A large body of literature has shown that CPPs (cell-penetrating peptides) are capable of carrying macromolecules across the plasma membrane. CPPs can penetrate a wide variety of tissue types and enable modulation of intracellular targets with molecules that, by themselves, are incapable of penetrating cells. As a result, CPPs are recognized for their potential value in validating intracellular...

Diffuse optical imaging is an emerging medical imaging modality based on near-infrared and visible red light. The method can be used for imaging activations in the human brain. In this study, a deformable probabilistic atlas of the distribution of tissue types within the term neonatal head was created based on MR images. The use of anatomical prior information provided by such atlas in reconstr...