نتایج جستجو برای: histamine h1 receptors

تعداد نتایج: 248896  

Journal: :The American journal of pathology 2015
Kyoko Shimizu Tsugunobu Andoh Yoko Yoshihisa Tadamichi Shimizu

Sunburn, wound repair, and chronic renal failure with hemodialysis are usually accompanied by both pigmentation and itching. Proopiomelanocortin-derived α-melanocyte-stimulating hormone (α-MSH) is produced in response to external stimuli, such as UV irradiation, and is involved in cutaneous pigmentation. However, it is unclear whether α-MSH is also involved in the itching. We therefore investig...

ایازی, الهام, بنانج, مریم, شاهین, مریم السادات, پیری, مرتضی,

Background and Objective: Dopamine receptors and histamine influence anxiety-like behaviors. Furthermore, interaction between histamine and dopaminergic D1 receptors has been demonstrated in the modulation of some behavior. In the present study, we investigated the interaction between histamine and dopaminergic D1 receptors in the dorsal hippocampus in the anxiety behavior. Materials and Method...

2013
Kenichi Kanai Kazuhito Asano Atsuko Furuta Takeyuki Sanbe Harumi Suzaki

Background Uteroglobin (CC10) is well known to be an immuno-suppressive protein secreted from airway epithelial cells after inflammatory stimulation and function in development of allergic disorders. Although histamine H1 receptor antagonists are used for the treatment of allergic disorders, the influence of the agents on CC10 production is not well understood. In the present study, we examined...

2011
Bianca Esposito Guido Gambara Alexander M. Lewis Fioretta Palombi Alessio D’Alessio Lewis X. Taylor Armando A. Genazzani Elio Ziparo Antony Galione Grant C. Churchill Antonio Filippini

1Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Anatomy, Histology, Forensic Medicine and Orthopedic, Section of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy; 2Department of Pharmacology, University of Oxford, Oxford, United Kingdom; and 3Department of Chemical, Food, Pharmaceutical and Pharmacological Sciences and Drug and Food Biotechnology Center, U...

2012
Tasuku Akiyama Mirela Iodi Carstens Akihiko Ikoma Ferda Cevikbas Martin Steinhoff E. Carstens

Lightly touching normal skin near a site of itch can elicit itch sensation, a phenomenon known as alloknesis. To investigate the neural mechanisms of alloknesis, we have developed an animal model. Low-threshold mechanical stimulation of the skin normally does not elicit any response in naive C57/BL6 mice. Following acute intradermal (i.d.) injection of histamine in the rostral back, mechanical ...

Journal: :The Journal of pharmacology and experimental therapeutics 2005
Kurt Rasmussen Mark J Benvenga Frank P Bymaster David O Calligaro Ilene R Cohen Julie F Falcone Susan K Hemrick-Luecke Fionna M Martin Nicholas A Moore Laura K Nisenbaum John M Schaus Sarah J Sundquist David E Tupper Todd R Wiernicki David L Nelson

FMPD [6-fluoro-10-[3-(2-methoxyethyl)-4-methyl-piperazin-1-yl]-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulene] is a potential novel antipsychotic with high affinity for dopamine D2 (Ki= 6.3 nM), 5-HT(2A) (Ki= 7.3 nM), and 5-HT6 (Ki= 8.0 nM) human recombinant receptors and lower affinity for histamine H1 (Ki= 30 nM) and 5-HT2C (Ki= 102 nM) human recombinant receptors than olanzapine. Oral administ...

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