Degeneration of CA3-pyramidal neurons in hippocampus after intracerebroventricular kainic acid (KA) administration, a model of temporal lobe epilepsy, results in hyperexcitability within both dentate gyrus and the CA1 subfield. It also leads to persistent reductions in hippocampal glutamate decarboxylase (GAD) interneuron numbers without diminution in Nissl-stained interneuron numbers, indicati...

Aging impairs the competence of the hippocampus for synaptic reorganization after injury. This potentially is due to the inability of the aging hippocampus to up-regulate the critical neurotrophic factors for prolonged periods after injury to levels at which they can stimulate neurite outgrowth and facilitate synaptic reorganization. We hypothesize that the concentrations of neurotrophins in th...

introduction: calcium/calmodulin-dependent protein kinase ii (camkii) is highly expressed in the hippocampus, which has a pivotal role in reward-related memories and morphine dependence. methods: in the present study, morphine tolerance was induced in male wistar rats by 7 days repeated morphine injections once daily, and then gene expression profile of α-isoform of camkii (camkiiα) in the hipp...

The cover image is based on the Research Article Parallel streams of raphe VGLUT3-positive inputs target dorsal and ventral hippocampus in each hemisphere by Justine Fortin-Houde et al., https://doi.org/10.1002/cne.25452

OBJECTIVES To explore volume changes of the entorhinal cortex (ERC) and hippocampus in mild cognitive impairment (MCI) and Alzheimer's disease (AD) compared with normal cognition (NC); to determine the powers of the ERC and the hippocampus for discrimination between these groups. METHODS This study included 40 subjects with NC, 36 patients with MCI, and 29 patients with AD. Volumes of the ERC...

OBJECTIVES Estrogen is an important hormone for cell growth, development, and differentiation by transcriptional regulation and modulation of intracellular signaling via second messengers. The reduction in the estrogen level after ovariectomy may lead to cognitive impairments associated with morphological changes in areas of the brain mediate memory. The aim of the present study was to find out...

Background Familial hypercholesterolemia (FH) is a clinical condition characterized by increased plasma cholesterol levels, due to mutation in the gene encoding low-density lipoprotein receptor (LDLr) cells [Brown and Goldstein, 1984]. Importantly, evidence indicates that FH negatively affects cognition favors development of neuropathologies [Ariza et al., 2016; Zambón al, 2010], however, mecha...

Background Numerous studies have identified an increased risk for Alzheimer’s dementia (AD) in Type II Diabetes (T2D). However, the T2D biological characteristics contributing to this are still unknown. Adiposity assessed by body mass index (BMI) is one of main causes and has been consistently linked higher risk, faster cognitive decline, related neural injury. contribution fat specifically can...

Traumatic brain injury (TBI) can occur at any age, from youth to the elderly, and its contribution age-related neuropathology remains unknown. Few studies have investigated relationship between age-at-injury pathophysiology a discrete biological age. In this study, we report immunohistochemical analysis of naïve rat brains compared those subjected diffuse TBI by midline fluid percussion (mFPI) ...

Background Alzheimer’s disease (AD) is characterised by the accumulation of amyloid-β and tau in brain subsequent neurodegeneration. The relationship between glucose metabolism has been elucidated AD, however two early stages AD trajectory remains elusive. Here, we examine this using fluorodeoxyglucose (FDG) flortaucipir (FTP) positron emission tomography (PET) a cohort cognitively normal older...