At Chapel Hill, Chapel Hill, North Carolina; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Sistemas Locales de Atención Integral a la Salud, León (SILAIS-León), Leon, Nicaragua; Hospital Escuela Oscar Danilo Rosales Argüello (HEODRA), León, Nicaragua, Leon, Nicaragua; Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill...

In this study, activated carbons prepared from agrowastes by chemical activation were used to remove acetic acid an aqueous solution through a batch process. The adsorbents characterized SEM, XRD, FT-IR, and point of zero charge (pHpzc). effects adsorbent dosage, initial concentration, contact time considered. Equilibrium data was tested using Langmuir, Freundlich, Temkin, Frenkel–Halsey–Hill m...

W. Gao, H. Zhu, K. Giovanello, K. Smith, D. Shen, J. Gilmore, and W. Lin Department of Biomedical Engineering, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, United States, Department of Biostatistics and BRIC, University of North Carolina-Chapel Hill, Department of Psychology and BRIC, University of North Carolina-Chapel Hill, Department of Radiology, University of Nort...

The effects of ruthenium red and the related compounds tetraamine palladium (4APd) and tetraamine platinum (4APt) were studied on the ryanodine activated Ca2+ release channel reconstituted in planar bilayers with the immunoaffinity purified ryanodine receptor. Ruthenium red, applied at submicromolar concentrations to the myoplasmic side (cis), induced an all-or-none flickery block of the ryanod...

Many learning tasks involve searching through a discrete space of performance elements, seeking an element whose future utility is expected to be high. As the task of nding the global optimum is often intractable, many practical learning systems use simple forms of hill-climbing to nd a locally optimal element. However, hill-climbing can be complicated by the fact that the utility value of a pe...

When Jim Lyons-Weiler and I discussed what we might do with an Open Access journal on Cancer Informatics, we both felt that it was important to avoid loosing focus on what the end-point of both the research and its dissemination is. In all its forms cancer is inevitably an unpleasant affl iction that harms every aspect of the lives of sufferers and those who love them. Jim and I want this journ...

The effects of various intracellular anions on the G protein (GK)-mediated activation of the muscarinic K+ (KACh) channel were examined in single atrial myocytes isolated from guinea pig hearts. The patch clamp technique was used in the inside-out patch configuration. With acetylcholine (ACh, 0.5 microM) in the pipette, 1 microM GTP caused different magnitudes of KACh channel activation in inte...

The steady state relation between cytoplasmic Ca2+ concentration ([Ca2+]i) and force was studied in intact skeletal muscle fibers of frogs. Intact twitch fibers were injected with the dextran-conjugated Ca2+ indicator, fura dextran, and the fluorescence signals of fura dextran were converted to [Ca2+]i using calibration parameters previously estimated in permeabilized muscle fibers (Konishi and...

Awake versus Anesthetized: Layer-Specific Sensory Processing in Visual Cortex and 1 Functional Connectivity between Cortical Areas 2 3 Running Head: Anesthetics Disrupt Sensory Processing 4 5 Kristin K. Sellers, Davis V. Bennett, Axel Hutt , James H. Williams, and Flavio Frohlich 6 7 1 Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill NC 27599 8 2 Neurobiology C...