The improved analytical characteristics of both sensitive and high-sensitivity assays for cardiac troponins I (cTnI) and T (cTnT) have substantially increased the diagnostic sensitivity for early detection of acute myocardial infarction (AMI) (1–3 ). With the ability to detect small increases in circulating cardiac troponins, any cause of myocardial injury will now produce a substantially great...

time after HT (R = -0.49; P = .0001). The ROC curve of hs-TnT for detecting AR was 0.682 (95%CI, 0.54-0.81; P = .01). A hs-TnT concentration < 17 ng/L ruled out AR with a sensitivity and a negative predictive value of 100%, but a specificity of 13% (Table 2); there were 29 true negatives for AR with hs-TnT < 17 ng/L. In a mixed-effects logistic regression model, the hs-TnT values were log trans...

Methods From January 2004 until June 2013, all consecutive critically ill patients undergoing primary PCI for STEMI at the University Medical Center Groningen were included in a registry and 1-year follow-up was obtained. Our primary endpoint consisted of the composite endpoint of myocardial infarction, target vessel and target lesion revascularization, and all-cause mortality (MACE). The secon...

Interest in the use of cardiac troponin T (cTnT) and cardiac troponin I (cTnI) has expanded from diagnosis of acute myocardial infarction to risk assessment for morbidity and mortality. Although cTnT and cTnI were shown to have equivalent diagnostic performance in the setting of suspected acute myocardial infarction, potential prognostic differences are largely unexplored.The aim of this study ...

BACKGROUND The current study aimed to investigate the release of myocardial high-sensitive Troponin T (hsTnT) in patients with pulmonary arterial hypertension (PAH) in response to maximal physical exercise. METHODS In 24 patients with PAH, symptom-limited cardiopulmonary exercise testing was performed. hsTnT was measured by the novel hsTnT assay with a lower limit of detection of 2 ng/L and a...

BACKGROUND AND OBJECTIVES Chest pain is one of the most frequent presenting complaints among patients arriving to the Emergency Department. In this population, the prevalence of acute coronary syndrome is about 25% instead that of acute myocardial infarction ranges from 5 to 15%. The diagnostic challenge for the emergency physician is the early rule-in or rule out of acute myocardial infarction...

INTRODUCTION The high-sensitive C-reactive protein (HS-CRP) assay is being increasingly used as a marker for cardiac risk assessment and as a prognostic tool in heart disease. In current study, we assessed the relationship between serum level of HS-CRP and extension of myocardial involvement in acute myocardial infarction. METHODS In a cross-sectional study, 50 patients with the final diagnos...