Principal component analysis (PCA), homozygosity rate estimations, and linkage studies in humans are classically conducted through genome-wide single-nucleotide variant arrays (GWSA). We compared whole-exome sequencing (WES) and GWSA for this purpose. We analyzed 110 subjects originating from different regions of the world, including North Africa and the Middle East, which are poorly covered by...

Wireless sensor networks have recently received increased attention for a broad array of applications such as surveillance, environment monitoring, medical diagnostics, and industrial control. A wireless sensor network (WSN) contains numerous small sized sensor nodes that have computation power. In WSNs serious incident data collected by the sensor nodes are to be reliably delivered to the sink...

It is well known that Induction motors are used worldwide as the “workhorse” in industrial applications. Although, these electromechanical devices are highly reliable, they are susceptible to many types of faults. Such fault can become catastrophic and cause production shutdowns, personal injuries and waste of raw material. However, induction motor faults can be detected in an initial stage in ...

Web services (WS) — the most prominent technology for realizing service oriented architectures — are broadly pushed by vendors and are likely to be deployed in dependability demanding areas such as air traffic control, health care, or transportation in the near future. However, although a plethora of WS standards exists, only few of them address dependability, namely specifications for transact...

Motivated by the desire for high-throughput public databases (i.e., “blockchains”), we design incentive compatible protocols that run “off-chain”, but rely on an existing cryptocurrency to implement a reward and/or punishment mechanism. Our protocols are incentive compatible in the sense that behaving honestly is a weak Nash equilibrium, even in spite of potentially malicious behavior from a sm...

RNA-binding protein (RBP) is a key player in regulating gene expression at the posttranscriptional level. CLIP-Seq, with the ability to provide a genome-wide map of protein-RNA interactions, has been increasingly used to decipher RBP-mediated posttranscriptional regulation. Generating highly reliable binding sites from CLIP-Seq requires not only stringent library preparation but also considerab...

A major pathway for bacterial preprotein translocation is provided by the Sec-dependent preprotein translocation pathway. Proteins destined for Sec-dependent translocation are synthesized as preproteins with an N-terminal signal peptide, which targets them to the SecYEG translocase channel. The driving force for the translocation reaction is provided by the peripheral membrane ATPase SecA, whic...

This paper describes the development of a novel humanoid robot foot/ankle based on an orientation Parallel Kinematic Mechanism for intelligent and flexible control. With three identical Universal-Prismatic-Spherical prismatic-actuated limbs and a central Universal-Revolute passive limb, the PKM can perform three degrees of freedom rotation motions. In order to enable the humanoid robot safely t...

Although multicast is an important communication primitive for parallel programming, many modern networks do not support it in hardware. Multicast can be implemented in software on such networks, using some spanning tree protocol. Making multicast reliable, however, is a difficult problem, even if the hardware point-to-point communication is reliable. The key issue is that a flow control mechan...