PURPOSE In this study endogenous magnetic resonance imaging (MRI) biomarkers for accurate segmentation of High Intensity Focused Ultrasound (HIFU)-treated tumor tissue and residual or recurring non-treated tumor tissue were identified. METHODS Multiparametric MRI, consisting of quantitative T1, T2, Apparent Diffusion Coefficient (ADC) and Magnetization Transfer Ratio (MTR) mapping, was perfor...

PURPOSE Ultrasound (US)-guided high intensity focused ultrasound (HIFU) has been proposed for noninvasive treatment of neuropathic pain and has been investigated in in-vivo studies. However, ultrasound has important limitations regarding treatment guidance and temperature monitoring. Magnetic resonance (MR)-imaging guidance may overcome these limitations and MR-guided HIFU (MR-HIFU) has been us...

BACKGROUND The availability of open and versatile software tools is a key feature to facilitate pre-clinical research for magnetic resonance imaging (MRI) and magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU) and expedite clinical translation of diagnostic and therapeutic medical applications. In the present study, two customizable software tools that were developed at the T...

UNLABELLED Study Type--Therapy (case series) Level of Evidence What's known on the subject? and What does the study add? Renal cancer is increasingly diagnosed when tumours are small and asymptomatic, during routine abdominal imaging. Whilst surgery is an effective and potentially curative option, it carries a significant risk of complications. Recent work suggests that thermally ablative thera...

Hypothesis: Extracorporeal high-intensity focused ultrasound (HIFU) would be used as a non-invasive local ablation for the treatment of patients with various kinds of solid tumor. Methods: A total of 1038 patients with solid tumors underwent HIFU ablation in ten Chinese hospitals. The tumors included primary and metastatic liver cancer, malignant bone tumors, breast cancer, soft tissue sarcomas...

Thermal ablation by High Intensity Focused Ultrasound (HIFU) is the only technique for noninvasive treatment of tumours, but suffers from a long treatment times and varied treatment outcomes. Knowledge of the nonlinear parameter B/A can resolve these by improving treatment planning, and correlation between enhanced nonlinear signals and the presence of HIFU lesions has the potential to monitor ...

High Intensity Focused Ultrasound (HIFU) technique is a noninvasive medical method for localized tissue heating, used mostly in treatment of tumors. The modality of HIFU utilizes focused ultrasound to raise the temperature of the tumor tissue in small localized volumes, resulting in necrosis. The ablation of the whole tumor, while taking into consideration all safety aspects of the treatment, i...

Passive cavitation images (PCIs) generated from scattered acoustic waves are a potential technique for monitoring lesion formation during high-intensity focused ultrasound (HIFU) thermal ablation. HIFU lesion prediction by PCIs was assessed in ex vivo bovine liver samples (N=14) during 30-s sonications with 1.1-MHz continuous-wave ultrasound (1989 W/cm^2 estimated spatial-peak intensity). Treat...

BACKGROUND/AIMS To evaluate the safety and efficacy of high intensity focused ultrasound (HIFU) therapy in patients with local advanced pancreatic cancer. METHODOLOGY 39 patients with local advanced pancreatic cancer were treated with HIFU, including 26 male and 13 female patients. The locations of the tumours were as follows: head of pancreas in 7 patients, body and/or tail of pancreas in 32...

PURPOSE To conduct a retrospective, single institutional and comparative study for radical retropubic prostatectomy (RRP), high dose rate brachytherapy (HDRBT), cryoablation and high-intensity focused ultrasound (HIFU) in localized prostate cancer with respect to oncological and functional outcomes. METHODS We reviewed 97, 161, 114 and 120 patients of RRP, HDRBT, cryoablation and HIFU respect...