Editor—We were surprised to read the letter of Bellomo and colleagues criticizing the Co-ordination Group for Mutual Recognition and Decentralised Procedures-human (CMDh) position related to the benefit/risk evaluation of hydroxylethyl starch (HES)-containing solutions. Since the conclusion of these EU Article 31 and 107i procedures is based on a review of all available safety and efficacy data...

Since 1998, when the first human embryonic stem (hES) cell lines were reported (Thomson et al., 1998), a large number of hES cell lines have been derived from the inner cell mass of preimplantation embryos donated at in vitro fertilization (IVF) clinics (Guhr et al., 2006). These hES cell lines possess remarkable ability of both unlimited self-renewal and pluripotency to generate any cell type ...

R. P. Goodrich and co-workers, 1989 have reported that red blood cells (RBCs) can be preserved in the dry state by addition of mixtures of hydroxyethyl starch (HES) and glucose (59,60). In this thesis work we tried to investigate the effect of HES alone on the viability, functionality and oxidative state of red blood cells after freeze thaw stress. Here we prepared eight formulations having var...

We report the histopathologic and dermatologic manifestations of eight patients with hypereosinophilic syndrome (HES). Skin lesions occurred in eight patients (53%) in a group of 15 patients with HES, and were generally of two types: (1) erythematous pruritic papules and nodules, or (2) urticaria and angioedema. As HES was treated with appropriate therapy, the skin lesions improved. Skin erupti...

The objective of this investigation was to study the gastrointestinal and hepatic involvement in hypereosinophilic syndrome (HES). Gastrointestinal or hepatic involvement is estimated to affect up to one-third of patients with HES, although most of the clinical evidence has been derived from case reports. In literature, HES presenting with hepatitis and jaundice with subsequent development of c...

Hydroxyethyl starch (HES) solution is an effective colloidal infusion solution in humans for treatment of hypovolaemic shock, but it has not been compared with fluids currently available for use in horses. On the basis of plasma-expanding effect of HES in normal horses, a 10% medium-molecular 200/0.5 solution of HES was subsequently tested in hypovolaemic horses. Six normal horses were given fi...

As the electricity sector evolves, and as all energy types (thermal, electric, chemical, etc.) become more coupled, there has been increased interest to develop deploy hybrid systems (HES). This work focuses on fully integrated HES, where are multiple sources products, often coupled through a storage buffer. A significant amount of available literature this describes technology pathways for HES...

The purpose of this study was to explore the potential formulating hesperetin into an ophthalmic solution with dipotassium glycyrrhizinate (DG) as a micelle nanocarrier. A DG-based encapsulating (DG-Hes) developed and its in vitro/in vivo characterizations were evaluated. optimal formulation featured DG/hesperetin (Hes) weight ratio 12:1 encapsulation efficiency 90.4 ± 1.7%; optimized DG-Hes ch...

The cell-substrate interface plays a key role in the regulation of cell behaviour. Defining the properties of this interface is particularly important for human embryonic stem (hES) cell culture, because changes in this environment can regulate hES cell differentiation. It has been established that fibronectin-coated surfaces can promote the attachment, growth and maintenance of the undifferent...

BACKGROUND Hydroxyethyl starch (HES) solutions alter blood coagulation, mainly platelet function and fibrinogen polymerization. Haemostasis can also be impaired by dilutional-hyperchloraemic acidosis induced by the HES carrier solution. We hypothesized that a saline-based tetrastarch carrier solution impairs parameters of blood coagulation more than a balanced carrier solution. METHODS The st...