Herpes simplex encephalitis (HSE) is a severe neurological disease in children and adults caused by herpes simplex virus. This review discusses recent findings on the role of Toll-like receptor 3 (TLR3) deficiencies in the HSE development. Critical checkpoints in the TLR3 signaling that contribute to innate response are discussed, including the importance of TLR3 ligand recognition site and tra...

Although object orientation in the human brain has been discussed extensively in the literature, the nature of the underlying cognitive representation(s) remains uncertain. We investigated orientation perception in BC, a patient with bilateral occipital and parietal damage from a herpes encephalitis infection. Our results show that in addition to general inaccuracy in discriminating and reprodu...

Dra. Marcela Fiol – Montañeses 2325, Cap Federal CP 1428 Buenos Aires Argentina. E-mail address: [email protected] Encephalitis is usually an acute or subacute infectious disease presenting variable symptoms including headache, confusion, seizures and obnubilation, with Herpes simplex virus (HSV) as one of its most frequent etiological agents. Occasionally, clinical presentation may be subtle,...

Seroepidemiological investigations were done during the study of viral encephalitis in and around Karachi, Pakistan. Serum and /or cerebrospinaF fluid (CSF) from 352 persons (72 patients with encephalitis, 199 patients without neurological disease and 81 healthy volunteers) were collected during the period from June, 1983 to March, 1984. Of 72 encephalitis patients, serum antibody positivity ra...