purpose: to evaluate the clinical manifestations and results of lensectomy in patients with hereditary lens subluxation at labbafinejad medical center, tehran-iran from 1996 t 2003. method: in an interventional case series, records of patients with hereditary lens subluxation who had undergone lensectomy were reviewed. patients with at least 6 months of follow up were included. background disea...

Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease in which glomerulonephritis represents one of the most severe clinical presentations. Numerous linkage and association studies, as well as the analysis of murine models, have provided ample evidence for a genetic basis for SLE. Genetic susceptibility to SLE results from the combined actions of multiple alleles, each ...

These observations established the presence of anti-GBM antibodies in the sera and/or kidneys of six humans with glomerulonephritis. Further, it seems clear that these antibodies do combine with the host's glomeruli in vivo and with GBM antigen of several species in vitro. Transfer of acute glomerulonephritis to normal recipient monkeys was possible with serum or renal eluate IGG from the three...

It is axiomatic that in the absence of acceptable descriptive terms that could be replicated, drawings of nephritic kidneys were a priceless asset and provided the greatest contribution to our present-day image and understanding of the types of lesions that the nineteenth century renal physicians were depicting. Although injected Malpighian corpuscles or glomeruli could be seen on the surface o...

Systemic lupus erythematosus is a generalized autoimmune disease affecting multiple end-organs including the kidneys. Glomerulonephritis is a leading cause of death in lupus, both in patients and murine models that develop disease spontaneously. Genetic mapping studies have uncovered several genetic intervals that confer susceptibility to nephritis both in human beings and in mice. This review ...

Fc receptors represent a distinct group of hematopoeitic cell surface glycoproteins that have a characterized role in affecting the efficiency of the mononuclear phagocyte system to clear IgG immune complexes. Functional genetic variations in this family of receptors have been identified as heritable susceptibility factors for SLE and lupus nephritis across diverse populations. In this review, ...

Although the study of experimental nephritis by physiological methods shows that the most striking effect of cantharidin is injury of the blood vessels, the great abundance of mitotic figures in the tubular epithelium in the stage of repair points to an equally widespread and severe epithelial injury. Caution must therefore be observed in ascribing the physiological disturbances of kidney funct...

Granulomatous interstitial nephritis has been observed in <1% of native renal biopsies. Here, we describe two patients with granulomatous interstitial nephritis in relation to Crohn's disease. Circulating helper and cytotoxic T cells were highly activated, and both cell types predominated in the interstitial infiltrate, indicating a cellular autoimmune response. After immunosuppressive treatmen...

let $m$ be a right module over a ring $r$, $tau_m$ a preradical on $sigma[m]$, and$ninsigma[m]$. in this note we show that if $n_1, n_2in sigma[m]$ are two$tau_m$-lifting modules such that $n_i$ is $n_j$-projective ($i,j=1,2$), then $n=n_1oplusn_2$ is $tau_m$-lifting. we investigate when homomorphic image of a $tau_m$-lifting moduleis $tau_m$-lifting.

This study was carried out to determine the prevalence and type of renal lesions in cattle that were slaughtered at the Ghaem (Shahriar) and Ziaran (Ghazvin) abattoirs. A total number of 405 clinically normal cattle were randomly selected and renal samples were taken for histopathological study. The cattle were divided into two groups according to sex, and female groups were divided into two ag...